St. Louis Cardinals vs CH Cubs Cubs Odds

As the MLB season heats up, the clash between the St. Louis Cardinals and the Chicago Cubs on September 28, 2025, promises to be a thrilling encounter at Wrigley Field in Chicago, IL. The Cubs, with home advantage, are currently favored with odds of -170, while the Cardinals are at +143. This game could be pivotal as both teams jockey for position in the league standings. The Cubs are looking to leverage their home-field advantage at the iconic Wrigley Field, a venue known for its vibrant atmosphere.

For avid bettors, understanding the odds can offer a significant edge. The run line for this matchup is set at -1.5 -110 for the Cubs and +1.5 -110 for the Cardinals. With the game broadcasted on FDSMW, fans and bettors alike will have the chance to catch all the action live. The best odds available today for the Cubs is -170 at Caesars and for the Cardinals +143 at Caesars.

Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge. For more insights and to compare the latest odds, visit our MLB odds page. As the line changes, it reflects the fluctuating dynamics of team strategies and player performances, offering bettors an opportunity to capitalize on the shifts.