Pittsburgh Pirates vs Cincinnati Reds Betting Trends

The excitement is palpable as the Cincinnati Reds prepare to host the Pittsburgh Pirates at the Great American Ball Park in Cincinnati, OH, on September 25, 2025. This MLB showdown promises to be a thrilling encounter with both teams looking to make a mark. For the Reds, Nick Lodolo takes the mound. This talented LHP boasts an 8-8 record with a 3.435 ERA and a 1.0848 WHIP, making him a formidable opponent. On the other side, the Pirates counter with Braxton Ashcraft, whose 4-3 record, 2.617 ERA, and 1.1939 WHIP showcase his prowess.

In terms of betting trends, the Reds are favored with a -165 Moneyline at Caesars, while the Pirates are at +140. The spread sees the Reds at -1.5 with a +130 price, whereas the Pirates are at +1.5 with a -155 price. Given the Reds' recent struggles against the spread, having a 43-37 ATS home record as seen on our MLB standings page, bettors might want to consider the Pirates' strong away ATS record of 37-40. The total points line is set at 8, with the OVER favored at -115.

As for game insights, the Reds have shown vulnerability against right-handed pitchers, a factor that Ashcraft will look to exploit. The Pirates, meanwhile, need to capitalize on Lodolo's weaker performance against right-handed batters. With both teams having solid pitching stats, this game could be a low-scoring affair. Don't miss out on the action live on SportsNet PT, FDSOH, and FDSNOH. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.

• The Reds have a 80-78-0 straight-up record, while the Pirates hold a 69-89-0 record.
• The Reds' fielding percentage stands at .985, compared to the Pirates' .987.
• In their last matchup, the Pirates edged out the Reds 4-3 on September 24, 2025.