Sep 25, 2025 6:40 PM EDT

Cleveland

(L) P. Messick

CLE

-145o7½ (-115)

CLEG

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Detroit Tigers vs Cleveland Guardians Odds

Updated:Sep 25, 2025 12:23 PM EDT

The upcoming MLB clash on September 25, 2025, between the Detroit Tigers and Cleveland Guardians at Progressive Field in Cleveland, OH, promises to be an exciting matchup. The Guardians, playing at home, are currently favored with a Moneyline of -145 at Caesars, while the Tigers stand at +122. The run line sees the Guardians at -1½ +150 and the Tigers at +1½ -178. Bettors should also note the total is set at 7.5, with the over at -115 and the under at -105.

As the Guardians aim to capitalize on their home advantage, the Tigers will look to upset the odds and secure a vital win. This game is a critical part of the MLB season, and with the Guardians' strong home performance, they are poised to make a statement. Fans can tune in to watch the game on CLE TV at 6:40 PM.

Understanding these odds is crucial for making informed betting decisions. The current odds reflect the Guardians' recent form and home advantage, while the Tigers' odds suggest potential value for those looking to back an underdog. For more in-depth MLB insights and to see how the odds have moved, visit our MLB odds page. Ready to elevate your betting strategy? Start your OddsTrader Turbo subscription today or place your bet with a U.S. regulated sportsbook to take advantage of these odds.

What are the odds for the Detroit Tigers vs Cleveland Guardians?

MLB

ODDS PICKS PLAYER PROPS FUTURES PLAYER FUTURES INJURIES WEATHER RANKINGS STANDINGS

Money

Run Line
Money
Total
Merged

Game

Game
1st 5

Today

Yesterday

Personalize your notifications and get updates on the teams, players or events you care about most. DELAYED PITB. Ashcraft (R) 69-89 74% +150Bet365
CINN. Lodolo (L) 80-78 26% -170Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. STARTS IN 00:40:02 FDSSUN... TBD. Rasmussen (R) 77-81 25% -110Caesars
BALC. Povich (L) 74-84 75% +100BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. THU 09/252:35 PM MINB. Ober (R) 68-90 90% +128BetRivers
TEXT. Mahle (R) 80-78 10% -144FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. THU 09/253:35 PM HOUF. Valdez (L) 84-74 26% -115Caesars
ATHJ. Ginn (R) 75-83 74% +102FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. THU 09/253:40 PM LADY. Yamamoto (R) 89-69 16% -164FanDuel
AZJ. Beeks (L) 80-78 84% +145BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. THU 09/256:05 PM MIAJ. Junk (R) 77-81 76% +143BetRivers
PHIW. Buehler (R) 93-65 24% -155Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. THU 09/256:40 PM DETT. Melton (R) 85-73 47% +128BetRivers
CLEP. Messick (L) 86-72 53% -145Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. THU 09/257:05 PM CWSD. Martin (R) 58-100 95% +265BetRivers
NYYC. Rodón (L) 90-68 5% -295BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. THU 09/257:07 PM BOSB. Bello (R) 87-71 95% +120Bet365
TORL. Varland (R) 90-68 5% -138FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. THU 09/257:40 PM NYMN. McLean (R) 81-77 26% -108FanDuel
CHCS. Imanaga (L) 89-69 74% -105Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. THU 09/259:38 PM KCM. Lorenzen (R) 79-79 6% -112FanDuel
LAAM. Farris (L) 71-87 94% +100Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. THU 09/259:40 PM COLB. Blalock (R) 43-115 - +195BetRivers
SEAUndecided 89-69 - -210BetMGM

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