Detroit Tigers Vs Cleveland Guardians Picks

The upcoming clash between the Detroit Tigers and Cleveland Guardians on September 23, 2025, at Progressive Field in Cleveland, OH, is set to be an exciting matchup. As part of the MLB regular season, both teams are looking to make a statement. Our prediction model suggests a close game with the Cleveland Guardians slightly favored to win with a predicted score of 3.48 to Detroit's 4.11. The probability of Cleveland covering the -1.5 spread is 58.8%, offering a solid betting opportunity. For those looking to play it safe, betting on Detroit with a +1.5 spread could be a viable option, although the probability is lower at 41.2%.

Our prediction model has been profitable in the last 10 games, winning 6 of them, particularly in the American Total market. For this game, the predicted total score is 7.59, with a slightly higher probability of the score going under 7.5. Considering the starting pitchers' performance against right-handed hitters, look for Cleveland to capitalize on this matchup. Catch the game live on CLEG and make sure to visit our MLB picks page for more insights.

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