- Run Line
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- Merged
The Cleveland Guardians face the Detroit Tigers at Comerica Park in Detroit, MI, on May 21, 2026, in an MLB regular season game broadcast on DSN. Current odds show Detroit favored on the moneyline at -113, with Cleveland at +103. The run line opened at -1.5 -110 for Detroit and +1.5 -110 for Cleveland, now shifted to -1.5 -215 and +1.5 +183 respectively, indicating increased confidence in Detroit's margin. The over under stands at 7.5 runs with betting lines favoring the under at -128. These odds reflect recent market adjustments and provide insights for bettors analyzing this matchup. For comprehensive MLB betting odds, see MLB odds page.
TBC. Legumina (R) 44-3343% -132Bet105 | |||||||
PITB. Chandler (R) 40-4073% +135Everygame | |||||||
SFL. Roupp (R) 33-4655% -122Bookmaker | |||||||
![]() DETT. Melton (R) 34-4670% -108BetAnything | |||||||
WSHC. Cavalli (R) 41-4071% +170Bookmaker | |||||||
![]() TORK. Gausman (R) 39-4121% -144Bet105 | |||||||
NYMF. Peralta (R) 34-4616% -105Bet105 | |||||||
BOSC. Early (L) 32-4672% +145Everygame | |||||||
STLM. McGreevy (R) 42-3613% -129BetOnline |