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The Cleveland Guardians will face the Detroit Tigers on May 21, 2026, at Comerica Park in Detroit, MI, in an MLB regular-season matchup broadcast on DSN. Our picks and betting tips favor Cleveland with a predicted score of 3.63 to Detroit's 3.97, indicating a close contest. Cleveland's hitters generally perform well against right-handed pitchers, which aligns with the expected starting pitcher profile. Our model shows a 62.8% probability of Cleveland covering the +1.5 spread, reflecting a strong betting value. Over the last 10 games, our predictions have maintained a positive hit rate and EV, especially on point spread markets. For more detailed analysis, visit the MLB picks and predictions page.
![]() DETF. Valdez (L) 33-44100% +115Everygame | |||||||
TBD. Rasmussen (R) 43-310% -184Bet105 | |||||||
MIAT. Phillips (R) 40-3833% -118BetOnline | |||||||
WSHF. Griffin (L) 40-38- -111MyBookie | |||||||
![]() TORS. Bieber (R) 38-39- -115BetOnline | |||||||
CINB. Singer (R) 37-39100% +145BetOnline | |||||||
NYMK. Senga (R) 34-43100% +104Bookmaker | |||||||
![]() CWSA. Kay (L) 39-3725% +100Bet105 | |||||||
![]() MINZ. Matthews (R) 38-41100% +139BetAnything | |||||||
STLA. Pallante (R) 41-3440% -135BetOnline | |||||||
![]() COLR. Feltner (R) 30-48100% +112Bet105 | |||||||
LAAS. Aldegheri (L) 32-4750% +143BetOnline | |||||||
![]() SDM. King (R) 39-37- -102BetOnline |