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FINAL
Nov 21, 2025 7:00 PM EST
IND 109 vs CLE 120
CLE
-13½ (-113)o241½ (-113)
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Indiana Pacers vs Cleveland Cavaliers Picks
Updated:Nov 21, 2025 1:09 AM EST
The NBA regular season game on November 21, 2025, features the Indiana Pacers facing off against the Cleveland Cavaliers at Rocket Arena in Cleveland, OH. This game promises exciting basketball action as both teams look to make a strong statement early in the 2025-26 season. The match will be broadcast on Amazon Prime Video, making it easily accessible to fans and bettors alike.
Our picks suggest the Cleveland Cavaliers will dominate this matchup with a predicted score of 125 to 113 over the Indiana Pacers. The Cavaliers are favored with a -13.5 point spread, which aligns with our prediction model's strong confidence. Our betting tips highlight a 54.6% hit rate and a positive EV of 3.4% on Indiana +13.5, but the best bet remains on Cleveland covering the spread. This is supported by our model's profitable outcomes in recent games, where the point spread market has shown consistent value and a high hit rate.
For bettors looking to capitalize on these insights, our comprehensive NBA picks page offers detailed predictions and trends to help make smarter wagers. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.
UPCOMING GAME PREDICTION
Spread
Money
Total
INDSpread
CONSENSUS LINE
+13½ (-105)
PROJECTION
CLE (127) - IND (115)
COVER PROBABILITY
EXPECTED VALUE
+1.1%
BET RATING
SEASON COVER %
6/15
40%
NBA
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NBATue 04/21
 Boston 57-2629% -14 -110BetAnything | |||||||
 San Antonio 63-2121% -11 -110BetOnline | |||||||
 L.A. Lakers 54-2928% +5 -103Bookmaker | |||||||
 Detroit 60-2358% -9½ -107Bet105 | |||||||
 Oklahoma City 65-1815% -16½ -115Bet105 | |||||||
 Atlanta 47-37100% +1 -110Heritage | |||||||
 Toronto 46-3833% +3½ -115Bet105 | |||||||
 Minnesota 50-340% +2 -110Bookmaker |
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