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The upcoming NBA game on April 21, 2026, features the Portland Trail Blazers visiting the San Antonio Spurs at Frost Bank Center in San Antonio, TX. Broadcast live on NBC/Peacock, this matchup is part of the 2025-26 NBA season. Our picks predict a San Antonio victory with a final score of 116-105, favoring the Spurs by 11.5 points. The Spurs have an 83.6% coverage percentage and -1.9% EV on the 2-way market, while Portland holds a 50.5% coverage on the spread. Our model has been profitable in recent games, especially with point spread bets, showing a positive hit rate and EV. For detailed analysis, visit our NBA picks and predictions page.