Betting Trends Duke Blue Devils vs Louisville Cardinals

The upcoming NCAAB matchup on January 6, 2026, between the Duke Blue Devils and Louisville Cardinals at KFC Yum! Center in Louisville, KY, promises an exciting clash. This game offers valuable betting trends that bettors should consider. The Blue Devils have a 3-point shooting percentage of .354, slightly edging out Louisville's .353, while Louisville attempts more 3-pointers per game (34.57) compared to Duke's 28.07. Duke averages 87.3 points per game and allows 69.96 points, whereas Louisville scores 90.4 points and allows 72.02 points per game, showing Louisville's offensive strength but also a higher defensive rating of 95.4 compared to Duke's 92.4.

Both teams have strong starting fives, with Duke's key players likely to play despite minor injury concerns, and Louisville's lineup is solid and healthy. Duke holds a 13-1 straight-up record and has a 7-7 ATS record, while Louisville is 11-3 straight-up with a 9-5 ATS record, boasting an impressive 8-0 home record that bettors should note. The current point spread favors Duke by 1 point at -110 odds, with total points set at 162.5, making the over a tempting option given both teams' scoring capabilities.

The last matchup on March 15, 2025, saw Duke defeat Louisville 73-62 at Spectrum Center, a game that went under the total of 148.5 points. This history provides context for bettors analyzing trends and game stats. Bettors can leverage these game insights to make smart wagers, considering recent performances and key player stats. The game airs on ESPN, offering excellent viewing for fans and bettors alike. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.