Memphis Tigers vs Louisville Cardinals Betting Trends

The upcoming basketball showdown on December 13, 2025, between the Memphis Tigers and Louisville Cardinals at KFC Yum! Center in Louisville, KY, is set to be a thrilling NCAAB contest. The Louisville Cardinals have been strong at home with an 8-1 record and a 6-3 ATS record, while Memphis Tigers hold a 4-4 overall and a solid 7-1 ATS record, especially impressive with a 3-0 ATS on the road. This game will be broadcast on ESPN, offering fans and bettors a prime viewing experience.

Looking at the betting trends, Louisville boasts a higher field goal percentage at 47.2% compared to Memphis's 43.2%. Louisville also demonstrates better 3-point shooting efficiency at 36% versus Memphis's 32.4%. Defensively, Louisville's rating of 91.4 is superior to Memphis's 104.7, indicating a stronger defense. Memphis, however, has a slight edge in blocks and steals. The exact odds spread is -15.5 favoring Louisville, with a total points line set at 161.5. This suggests Louisville is the favorite to cover, but Memphis's strong ATS record on the road makes them a tempting underdog pick.

Key players to watch include Louisville's starting five who contribute significantly to their scoring and defensive stats, and Memphis's lineup that has shown resilience despite some injury questions. The betting stats and game insights suggest Louisville's offensive and defensive efficiency could dominate, but Memphis's aggressive defense could keep the game competitive. Bettors should consider these factors carefully when placing wagers.

For bettors looking to dive deeper, the previous matchup on December 16, 2017, saw Louisville win 81-72 against Memphis, which might offer some historical context. The Cardinals' strong home record and Memphis's road ATS success can be further explored on our NCAAB standings page. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.