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FINAL
Nov 21, 2025 6:30 PM EST
LOU 74 vs CIN 64
LOU
-8½ (+100)o164 (-110)
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Louisville Cardinals vs Cincinnati Bearcats Picks
Updated:Nov 21, 2025 1:20 AM EST
The highly anticipated NCAAB matchup between the Louisville Cardinals and Cincinnati Bearcats is set for November 21, 2025, at the Heritage Bank Center in Cincinnati, OH. This Friday's game promises exciting basketball action as these two teams face off in the regular season. Fans and bettors alike should tune in to catch the game broadcasted live on ESPNU.
Our expert picks favor the Louisville Cardinals to win with a predicted score of 87 to Cincinnati's 77, suggesting Louisville will cover the -8.5 point spread. Cincinnati is expected to put up a strong fight but fall short by about 10 points. This prediction is backed by a solid hit rate and EV in our point spread market, which has been profitable over the last 10 games, boasting a 52.1% hit rate and an EV of -0.3% for Louisville -8.5. The 2-way market also favors Louisville with an 83.1% confidence level and a positive EV of 2.2%.
Recent results show our predictions have been on point, with Louisville winning and covering spreads in their last contests, and Cincinnati showing strength but mixed results. Bettors can use these insights to make smarter bets, especially considering the strong historical performance of our predictions in similar matchups. For more expert NCAAB picks and betting tips, check out our comprehensive NCAAB picks and predictions.
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UPCOMING GAME PREDICTION
Spread
Money
Total
LOUSpread
CONSENSUS LINE
-8½ (-110)
PROJECTION
LOU (87) - CIN (77)
COVER PROBABILITY
EXPECTED VALUE
-0.3%
BET RATING
SEASON COVER %
2/4
50%
NCAAB
Live college basketball odds are always available at OddsTrader. You can keep up with your favorite teams or consider using our stats-driven NCAAB computer picks to help you make smarter wagers. Betting action intensifies during March Madness, making it crucial to track odds and betting lines in real time. New bettors can read on to learn more about NCAAB odds.
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