Louisville Cardinals vs Tennessee Volunteers Picks

The upcoming basketball showdown on December 16, 2025, features the Louisville Cardinals visiting the Tennessee Volunteers at Thompson-Boling Arena in Knoxville, TN. This highly anticipated NCAAB regular-season game will be broadcast on ESPN, offering fans nationwide a thrilling college basketball experience.

Our expert picks predict a closely contested game with Tennessee edging out Louisville 79-78. The Volunteers are favored on the moneyline with a -1.5 spread, reflecting a slight advantage at home. Our model shows a solid hit rate and positive expected value (EV) in recent point spread bets, with a 50.8% cover percentage and an EV of -0.7%, indicating profitable betting opportunities.

In the last 10 games, our predictions for the point spread market have been reliably profitable, winning more than half the time while maintaining a strong EV, which is a great indicator for bettors looking to make smart wagers. The 2-way market also shows promising hit rates, with Louisville covering at a 49.2% rate and Tennessee at 53.3%, supporting our confidence in these picks.

For those interested in detailed analysis and more NCAAB picks, check out our comprehensive NCAAB picks and predictions. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.