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The upcoming NCAA basketball game on December 21, 2025, features the Vanderbilt Commodores visiting the Wake Forest Demon Deacons at Lawrence Joel Veterans Memorial Coliseum in Winston-Salem, NC. This highly anticipated match-up will be broadcasted on The CW Network, giving fans and bettors a great opportunity to catch all the action live.
Our expert picks for the Vanderbilt Commodores vs Wake Forest Demon Deacons game highlight Vanderbilt as the favorite with a predicted score of 82 to 78. We recommend taking Vanderbilt at a -4.5 point spread, where our prediction model shows a 47.8% hit rate and an EV of -4.6%, indicating a solid betting edge. Wake Forest, meanwhile, is given a 53.4% hit rate at +5 on the spread with a positive EV of 1.0%, making it a viable underdog bet to consider.
Looking at recent results, our prediction model has been profitable in the last 10 games, especially in the 2-way markets where Vanderbilt has won 6 times and Wake Forest has performed well in covering spreads. This consistent performance provides bettors with confidence to make informed bets and parlays for this game. For more in-depth analysis and picks, check out our NCAAB picks and predictions.
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