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Nov 14, 2025 7:30 PM EST
Week 12
LOU
-2½ (-105)o51 (-110)
ESPN, 206MATCHUP
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Clemson Tigers vs Louisville Cardinals Picks
Updated:Nov 14, 2025 2:17 AM EST
The upcoming clash on November 15, 2025, between the Clemson Tigers and Louisville Cardinals at L&N Federal Credit Union Stadium in Louisville, KY, promises an exciting Friday football showdown in the 2025-26 NCAAF season. Broadcast live on ESPN, this game offers a thrilling opportunity for bettors to get in on the action. Our expert picks favor Clemson with a predicted score of 27 to Louisville's 25, backing Clemson on the point spread at 2.5 points. The predicted total score is just over 52, leaning towards the over 51 betting market with a positive expected value (EV) of 1.7% and a hit rate exceeding 51%.
Our prediction model has been profitable in recent games, especially with the over/under markets, winning 6 of the last 10 bets. This strong hit rate and positive EV make our betting tips a valuable resource for making smart wagers. By leveraging these stats, bettors can gain an edge in their betting strategy. For more insights and expert guidance, check out our comprehensive NCAAF picks and predictions.
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UPCOMING GAME PREDICTION
Spread
Money
Total
CLEMSpread
CONSENSUS LINE
+2½ (-114)
PROJECTION
CLEM (27) - LOU (25)
COVER PROBABILITY
EXPECTED VALUE
+4.7%
BET RATING
SEASON COVER %
3/9
33%
EXCLUSIVE BOOSTS
Boosts Available
Boosts are special bets with increased odds offered by sportsbooks for a limited time.
OTHER BETS
Fri 11/14 7:30 PMCLEM @ LOU
Keyjuan BrownReceptions
EV
+33.6%
+33.6%
Adam RandallReceiving Yards
EV
+23.9%
+23.9%
Cade KlubnikRushing Yards
EV
+21.9%
+21.9%
Keyjuan BrownRushing Yards
EV
+19.7%
+19.7%
Miller MossPassing Yards
EV
+12.6%
+12.6%
Adam RandallRushing Yards
EV
+12.0%
+12.0%
Cade KlubnikPassing Yards
EV
+11.7%
+11.7%
Miller MossPassing Touchdowns
EV
+7.9%
+7.9%
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NCAAF
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NCAAF Week 12
NCAAF Fri 11/14
 #20Louisville 7-229% -1½ -115BetMGM | |||||||
 #8Oregon 8-134% -24½ -115BetMGM | |||||||
 Connecticut 7-322% -7½ -105FanDuel | |||||||
 Charlotte 1-8100% +18½ -110FanDuel | |||||||
 #25Cincinnati 7-218% -6 -110Bet365 | |||||||
 Navy 7-223% +10½ -114BetRivers | |||||||
 #2Indiana 10-016% -29 -112Caesars | |||||||
 #22Pittsburgh 7-270% +12½ -110Caesars | |||||||
 Ball State 4-585% +2½ -106Caesars | |||||||
 Oklahoma State 1-875% +20 -117SugarHouse | |||||||
 #3Texas A&M 9-072% -17½ -110FanDuel | |||||||
 Northwestern 5-445% +11½ -115BetMGM | |||||||
 LSU 5-417% -5 -110Caesars | |||||||
 Tulsa 2-740% +2½ -106FanDuel | |||||||
 Arizona State 6-38% -11 -114SugarHouse | |||||||
 Kentucky 4-5- -21½ -110Bet365 | |||||||
 Georgia State 1-876% +8 -112BetRivers | |||||||
 UAB 3-678% +18½ -115FanDuel | |||||||
 New Mexico 6-317% -14 -115BetRivers | |||||||
 Missouri State 6-30% -4½ -105FanDuel | |||||||
 James Madison 8-170% -21 -109Caesars | |||||||
 Boston College 1-949% +17 -117SugarHouse | |||||||
 Duke 5-449% -4½ -110Caesars | |||||||
 #15Miami (FL) 7-26% -14½ -113BetRivers | |||||||
 Michigan State 3-677% +7½ -114FanDuel | |||||||
 #4Alabama 8-112% -5½ -113BetRivers | |||||||
 Southern Miss 7-237% -3 -110BetMGM | |||||||
 #6Texas Tech 9-187% -23½ -110BetMGM | |||||||
 Louisiana-Monroe 3-667% +4½ -105FanDuel | |||||||
 Illinois 6-310% -15 -113BetRivers | |||||||
 #17USC 7-224% -6 -117SugarHouse | |||||||
 Western Kentucky 7-20% -13 -121SugarHouse | |||||||
 Nevada 1-892% +9½ +102Caesars | |||||||
 East Carolina 6-373% -2½ -120BetRivers | |||||||
 Tulane 7-20% -17½ -110Caesars | |||||||
 #23Tennessee 6-31% -39½ -110BetMGM | |||||||
 Wake Forest 6-342% -5½ -115BetRivers | |||||||
 Florida International 4-575% +3 -118BetRivers | |||||||
 Georgia Southern 4-540% -3 -114Caesars | |||||||
 Sam Houston State 1-885% +10½ -118SugarHouse | |||||||
 Baylor 5-482% +9 -114BetRivers | |||||||
 #7Ole Miss 9-118% -11½ -105BetMGM | |||||||
 Washington 6-38% -16½ -110Bet365 | |||||||
 UNLV 7-212% -6 -110Bet365 | |||||||
 #5Georgia 8-168% -6 -110Bet365 | |||||||
 Florida State 4-515% -13½ -115BetRivers | |||||||
 #1Ohio State 9-035% -31½ -105Bet365 | |||||||
 Missouri 6-327% -6½ -118FanDuel | |||||||
 Jacksonville State 6-375% +3½ -118FanDuel | |||||||
 Washington State 4-58% -7½ -115Bet365 | |||||||
 #12Brigham Young 8-111% -3 -122BetRivers | |||||||
 Fresno State 6-329% -3½ -105BetMGM | |||||||
 San Diego State 7-237% -1½ -112FanDuel | |||||||
 Akron 4-735 -7 -118SugarHouse | |||||||
 Western Michigan 6-417 +2 -139SugarHouse | |||||||
 Massachusetts 0-103 +10 -110BetMGM | |||||||
 Miami (OH) 5-53 +5½ -105Bet365 | |||||||
 Central Michigan 6-438 -2½ -110BetMGM | |||||||
 Old Dominion 7-333 -9 -115BetRivers |
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