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The SMU Mustangs are gearing up to face the Clemson Tigers on October 18, 2025, at Memorial Stadium in Clemson, SC. This Saturday football matchup is a highly anticipated event in the NCAAF league, with both teams looking to assert dominance. The Mustangs come into this game after a strong 34-10 win against Stanford, while the Tigers are fresh off a 41-10 victory over Boston College. With the game airing on ACC Network, fans are in for a treat.
Betting trends suggest Clemson's stronghold at home might give them an edge, but don't count out SMU's explosive offense. The Tigers' pass defense has been solid, averaging 218.3 passing yards allowed per game, but they'll be tested by SMU's potent passing attack which averages 277.8 yards per game. Clemson's quarterback has been consistent, and their pass protection has held up well, allowing only 1.16 sacks per game. On the other hand, SMU's quarterback will need to navigate Clemson's aggressive pass rush.
The point spread is set at Clemson -9.5, with a total points line of 54.5. Clemson is favored, but SMU's ability to cover the spread makes this an intriguing bet. In their last encounter, Clemson narrowly defeated SMU 34-31, which you can check out on our last matchup page. With both teams having a history of close games, this could be another nail-biter. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.
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![]() South Alabama 1-537% -6½ -122FanDuel | |||||||
![]() Western Kentucky 5-133% -7½ -110Caesars | |||||||
![]() Jacksonville State 3-375% +2½ -112FanDuel | |||||||
![]() Sam Houston State 0-667% +3 -117BetRivers | |||||||
East Carolina 3-333% -16½ -110Caesars | |||||||
![]() #2Miami (FL) 5-019% -12½ -115FanDuel | |||||||
Minnesota 4-289% +6½ -110Caesars | |||||||
![]() Utah State 3-343% -4 -110Caesars | |||||||
![]() California 4-20% -10½ -110Caesars | |||||||
Miami (OH) 3-30% -12½ -110FanDuel | |||||||
![]() Boston College 1-540% -1½ -110Caesars | |||||||
![]() Duke 4-264% -2½ -115BetMGM | |||||||
Bowling Green 3-30% -5½ -110FanDuel | |||||||
![]() #17Vanderbilt 5-167% -2½ -110Caesars | |||||||
![]() Michigan 4-253% -5½ -106FanDuel | |||||||
![]() Houston 5-125% -1½ -108FanDuel | |||||||
TCU 4-220% -2½ -120FanDuel | |||||||
![]() Tulane 5-133% -10½ -110Caesars | |||||||
![]() South Carolina 3-3100% +5½ -110Caesars | |||||||
UCF 3-350% -7 -110Caesars | |||||||
![]() Toledo 3-3- -24½ -110BetRivers | |||||||
![]() Massachusetts 0-6100% +17½ -115Caesars | |||||||
![]() Louisiana-Monroe 3-3- +6½ -110BetRivers | |||||||
![]() Northwestern 4-20% -3½ -110Caesars | |||||||
Appalachian State 4-2- -11½ -110Caesars | |||||||
![]() Ohio 3-3- -11½ -115BetMGM | |||||||
![]() James Madison 5-10% -2 -110Caesars | |||||||
![]() Charlotte 1-5- +12½ -110FanDuel | |||||||
![]() Clemson 3-322% -9½ -110Caesars | |||||||
![]() #3Indiana 6-010% -26½ -113BetRivers | |||||||
Marshall 3-360% +3½ -113BetRivers | |||||||
Ball State 2-4- -1½ -105FanDuel | |||||||
![]() Boise State 4-267% -10½ -110Caesars | |||||||
![]() North Texas 5-150% -5½ -110Caesars | |||||||
![]() #9Georgia 5-130% -6½ -105BetMGM | |||||||
![]() Arkansas 2-474% +7½ -110Caesars | |||||||
![]() Wisconsin 2-485% +27½ -110Caesars | |||||||
Air Force 1-50% -4½ -115FanDuel | |||||||
UAB 2-4100% +21½ -110BetMGM | |||||||
![]() Arizona State 4-294% +10½ -110Caesars | |||||||
Florida 2-4100% -9½ -112BetRivers | |||||||
![]() Louisiana 2-4- +4 -110Caesars | |||||||
![]() #18Virginia 5-10% -17½ -104FanDuel | |||||||
Rutgers 3-3100% +15½ -110FanDuel | |||||||
![]() Georgia Southern 2-40% -6½ -113BetRivers | |||||||
![]() Colorado State 2-4100% +1 -117BetRivers | |||||||
UCLA 2-450% -2½ -118FanDuel | |||||||
Iowa 4-233% -2½ -118FanDuel | |||||||
Kentucky 2-350% +12½ -115BetMGM | |||||||
![]() #19South Florida 5-1- -21½ -110BetMGM | |||||||
Syracuse 3-3- +11½ -110Caesars | |||||||
#13Notre Dame 4-244% -7½ -110FanDuel | |||||||
#6Alabama 5-120% -8 -110Caesars | |||||||
Auburn 3-375% -1½ -110BetRivers | |||||||
Oklahoma State 1-5100% +21½ -112BetRivers | |||||||
#15Brigham Young 6-00% +3½ -120FanDuel | |||||||
![]() New Mexico 3-30% -10 -110BetRivers | |||||||
![]() Oregon State 0-7- - | |||||||
Stanford 2-4- +17½ -110Caesars |
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