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The upcoming Saturday football clash on November 29, 2025, between the Clemson Tigers and South Carolina Gamecocks at Williams-Brice Stadium in Columbia, SC, promises an exciting showdown in the 2025-26 NCAAF season. This game is set to be broadcast on SEC Network and ESPN networks, ensuring fans and bettors have great access to the action.
Our expert picks favor Clemson to win with a predicted score of 25 to 23, supporting a Clemson 2.5-point spread. The predicted total score is around 48. This prediction aligns well with our recent profitable point spread market that has a 55.2% hit rate and a 3.1% EV, indicating a positive expected value for bettors.
South Carolina has had mixed results recently, but Clemson's strong performance in the last 10 games, where our model has been successful in covering spreads and winning 6 out of 10 games, gives bettors an edge. Our betting tips suggest focusing on the point spread market with Clemson favored, as it offers the best chance for a profitable wager.
For more detailed insights and to enhance your betting strategy, check out our NCAAF picks page. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.
![]() Massachusetts 0-1174% +15 -115SugarHouse | |||||||
Eastern Michigan 4-775% +7½ -109Caesars | |||||||
![]() Memphis 8-344% -4½ -113BetRivers | |||||||
Buffalo 5-675% +7 -110Bet365 | |||||||
![]() Mississippi State 5-679% +7½ -120BetMGM | |||||||
Nebraska 7-479% +6½ -112BetRivers | |||||||
![]() Northern Illinois 3-850% -4½ -112FanDuel | |||||||
![]() Kansas 5-671% +12½ -110BetMGM | |||||||
![]() Colorado State 2-950% +2½ -110FanDuel | |||||||
![]() #16Georgia Tech 9-267% +13½ -105FanDuel | |||||||
![]() New Mexico 8-389% +1½ -110Bet365 | |||||||
![]() North Texas 10-120% -19½ -110Bet365 | |||||||
![]() Utah State 6-589% +3½ -114Caesars | |||||||
![]() #17Texas 8-376% +2½ -104FanDuel | |||||||
![]() Purdue 2-980% +28½ -108Caesars | |||||||
![]() #25Arizona State 8-325% +2 -109Caesars | |||||||
West Virginia 4-775% +24 -115SugarHouse | |||||||
![]() Florida Atlantic 4-786% +7 -105BetMGM | |||||||
Louisville 7-425% -3 -110Bet365 | |||||||
![]() South Carolina 3-725% -2 -110Bet365 | |||||||
![]() #18Michigan 9-277% +10½ -114BetRivers | |||||||
![]() Pittsburgh 8-367% +7 -109Caesars | |||||||
Central Michigan 7-467% +10½ -110BetMGM | |||||||
Miami (OH) 6-5- -17½ -110Bet365 | |||||||
![]() Kansas State 5-633% -17 -110Bet365 | |||||||
Baylor 5-643% -2½ -105Bet365 | |||||||
Oklahoma State 1-10100% +14½ -115FanDuel | |||||||
![]() Delaware 5-60% -5 -110Bet365 | |||||||
![]() Sam Houston State 2-9100% +11 -115SugarHouse | |||||||
#11Brigham Young 10-10% -17½ -110BetMGM | |||||||
Marshall 5-60% -7 -110Bet365 | |||||||
![]() Old Dominion 8-350% -26½ -110BetMGM | |||||||
![]() Missouri State 7-425% -2½ -115Caesars | |||||||
![]() Jacksonville State 7-433% +2½ -105Bet365 | |||||||
Appalachian State 5-6100% -2½ -109Caesars | |||||||
Syracuse 3-8100% +3½ -122FanDuel | |||||||
![]() Tulsa 4-70% -8 -117SugarHouse | |||||||
Texas State 5-60% -9½ -106Caesars | |||||||
![]() Louisiana 5-6- -10 -109Caesars | |||||||
New Mexico State 4-750% -4 -115BetMGM | |||||||
#20Tennessee 8-326% -2½ -110Bet365 | |||||||
![]() Duke 6-580% -1 -110Bet365 | |||||||
Rutgers 5-6100% +13½ -114FanDuel | |||||||
![]() #8Oklahoma 9-215% -10 -107Caesars | |||||||
![]() UTSA 6-540% -6½ -120FanDuel | |||||||
TCU 6-457% -3½ -110Caesars | |||||||
Southern Miss 7-467% -6 -120SugarHouse | |||||||
![]() Arkansas 2-993% +2½ -104FanDuel | |||||||
Minnesota 6-517% -1 -105Bet365 | |||||||
![]() Washington 8-381% +7 -117SugarHouse | |||||||
![]() Liberty 4-750% +2½ -110BetMGM | |||||||
![]() Coastal Carolina 6-5100% +22½ -110FanDuel | |||||||
Florida 3-80% +1½ -115BetMGM | |||||||
![]() Washington State 5-633% -13½ -110Caesars | |||||||
![]() South Florida 8-30% -27 -110Bet365 | |||||||
Michigan State 3-850% -3½ -110BetRivers | |||||||
![]() #19Virginia 9-225% -10 -112Caesars | |||||||
![]() North Carolina State 6-525% -7½ -105FanDuel | |||||||
Auburn 5-6100% +6 -115SugarHouse | |||||||
#24Tulane 9-20% -29½ -110BetMGM | |||||||
#21Illinois 7-412% -6½ -115Bet365 | |||||||
#15USC 8-260% -21½ -110FanDuel | |||||||
![]() California 6-589% +13½ -110BetMGM | |||||||
![]() Nevada 3-8100% +8½ -110Bet365 | |||||||
![]() San Jose State 3-875% +2½ -108FanDuel | |||||||
Stanford 4-7100% +32½ -108Caesars | |||||||
![]() Hawaii 7-433% -7½ -113BetRivers |
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