Nov 22, 2025 3:30 PM EST

Week 13

Duke

4-6

North Carolina

DUKE

-7 (-105)o51½ (-110)

ACC Network, 612

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Duke Blue Devils vs North Carolina Tar Heels Picks

Updated:Nov 22, 2025 1:47 AM EST

The much-anticipated Saturday football game on November 22, 2025, features the Duke Blue Devils visiting the North Carolina Tar Heels at Kenan Stadium in Chapel Hill, NC. This NCAAF regular season Week 13 matchup promises intense rivalry action and high stakes as both teams battle for conference supremacy.

Our expert picks favor Duke with a predicted score of 28 to 24 over North Carolina. The best bet is Duke +2.5 on the point spread, boasting a strong hit rate of 61.6% and a high EV of 9.2%. This betting tip is supported by our prediction model which has been profitable in recent games, especially in point spread markets, helping bettors make smarter wagers.

Fans can catch the action live on ACC Network, bringing all the excitement directly to your screens. The game is set at Kenan Stadium, a renowned outdoor venue known for its electric atmosphere during college football clashes.

For those looking to dive deeper, explore our comprehensive NCAAF picks and predictions to stay ahead of the game. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.

When is the Duke Blue Devils vs North Carolina Tar Heels game?

NCAAF

ODDS PICKS PLAYER PROPS FUTURES PLAYER FUTURES INJURIES WEATHER RANKINGS STANDINGS

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NCAAF Sat 11/22

Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:00 PM Rutgers 5-5 69% +31½ -112FanDuel
#1Ohio State 10-0 31% -31 -115BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:00 PM Tulsa 3-7 77% +10 -105BetMGM
Army 5-4 23% -9½ -118FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:00 PM Delaware 5-5 67% +18 -120BetRivers
Wake Forest 7-3 33% -17½ -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:00 PM #13Miami (FL) 8-2 75% -17½ -114FanDuel
Virginia Tech 3-7 25% +18 -109Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:00 PM #22Missouri 7-3 65% +5½ -105BetMGM
#8Oklahoma 8-2 35% -5½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:00 PM Louisville 7-3 46% +4 -110Caesars
SMU 7-3 54% -3½ -117SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:00 PM Kansas 5-5 66% +3½ -113Caesars
Iowa State 6-4 34% -3½ -105BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:00 PM Minnesota 6-4 60% +3½ -105Bet365
Northwestern 5-5 40% -3½ -110BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:00 PM Samford 1-10 - +55½ -110FanDuel
#3Texas A&M 10-0 - -54½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:45 PM Charlotte 1-9 37% +44 -110Bet365
#4Georgia 9-1 63% -43½ -112Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/221:00 PM Old Dominion 7-3 44% -10½ -110Bet365
Georgia Southern 5-5 56% +11 -115SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/221:00 PM Washington State 5-5 51% +14 -110BetMGM
James Madison 9-1 49% -13½ -120FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/221:00 PM Baylor 5-5 69% +7 -115Bet365
Arizona 7-3 31% -6½ -114Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/222:00 PM Ball State 4-6 31% +28½ -117Caesars
Toledo 6-4 69% -27½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/222:00 PM Nevada 2-8 74% +7½ -120FanDuel
Wyoming 4-6 26% -6½ -112Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/222:00 PM Missouri State 7-3 79% +6½ -109BetRivers
Kennesaw State 7-3 21% -6½ -105FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/222:00 PM Mercer 9-1 - +27½ -110Bet365
Auburn 4-6 - -27½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/222:00 PM Eastern Illinois 3-8 - +50½ -110FanDuel
#10Alabama 8-2 - -50½ -107Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/222:30 PM Marshall 5-5 27% -4½ -115FanDuel
Appalachian State 4-6 73% +5½ -115Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:00 PM Connecticut 8-3 16% -6½ -110Bet365
Florida Atlantic 4-6 84% +7½ -120FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:00 PM New Mexico State 3-7 76% +3½ -117BetRivers
UTEP 2-8 24% -3 -113Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:00 PM Sam Houston State 2-8 50% +6½ -104Caesars
Middle Tennessee 1-9 50% -6½ -113BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:00 PM Liberty 4-6 76% +2½ -130BetMGM
Louisiana Tech 5-5 24% +1½ -115FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:00 PM South Florida 7-3 27% -21½ -108FanDuel
UAB 3-7 73% +21½ -109Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:30 PM Duke 5-5 29% -6½ -114Caesars
North Carolina 4-6 71% +7 -115BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:30 PM Arkansas 2-8 87% +9 -110Bet365
#17Texas 7-3 13% -8 -115BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:30 PM #15USC 8-2 40% +10½ -112BetRivers
#7Oregon 9-1 60% -10 -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:30 PM Michigan State 3-7 41% +17½ -120FanDuel
Iowa 6-4 59% -16½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:30 PM East Carolina 7-3 33% -2½ -110Bet365
UTSA 5-5 67% +2½ -108Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:30 PM Kentucky 5-5 83% +9½ -110Bet365
#14Vanderbilt 8-2 17% -8 -115SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:30 PM Southern Miss 7-3 43% +1½ -115FanDuel
South Alabama 3-7 57% +1½ -115BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:30 PM Jacksonville State 7-3 40% +1½ -112FanDuel
Florida International 5-5 60% -1 -115Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:30 PM Syracuse 3-7 28% +36½ -105BetMGM
#9Notre Dame 8-2 72% -35 -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:45 PM #24Tulane 8-2 16% -9 -110Bet365
Temple 5-5 84% +9½ -105FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/224:00 PM Oklahoma State 1-9 77% +13½ -115Caesars
UCF 4-6 23% -13 -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/224:00 PM #18Michigan 8-2 28% -13½ -120FanDuel
Maryland 4-6 72% +14 -107Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/224:00 PM TCU 6-4 72% +1½ -110Caesars
#23Houston 8-2 28% -1 -113BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/224:00 PM Kansas State 5-5 31% +17½ -112BetRivers
#12Utah 8-2 69% -15½ -125BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/224:00 PM Georgia State 1-9 77% +10½ -110Bet365
Troy 6-4 23% -9½ -118FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/224:15 PM Coastal Carolina 6-4 41% +24 -108Caesars
South Carolina 3-7 59% -23½ -122FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/224:30 PM Furman 6-5 - +42 -110BetRivers
Clemson 5-5 - -41½ -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/225:00 PM Louisiana-Monroe 3-7 71% +20½ -110FanDuel
Texas State 4-6 29% -19½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/227:00 PM Pittsburgh 7-3 83% +2½ -105BetMGM
#16Georgia Tech 9-1 17% -2½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/227:00 PM Nebraska 7-3 66% +8 -115Bet365
Penn State 4-6 34% -7½ -113BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/227:00 PM Colorado State 2-8 100% +17½ -115BetMGM
Boise State 6-4 0% -16½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/227:00 PM New Mexico 7-3 11% -3½ -102FanDuel
Air Force 3-7 89% +4 -120SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/227:30 PM #20Tennessee 7-3 12% -3½ -118FanDuel
Florida 3-7 88% +4½ -112BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/227:30 PM California 6-4 19% -2½ -120FanDuel
Stanford 3-7 81% +3½ -113Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/227:30 PM #21Illinois 7-3 43% -8 -114BetRivers
Wisconsin 3-7 57% +8½ -110BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/227:30 PM North Texas 9-1 12% -17½ -115BetMGM
Rice 5-5 88% +18½ -115FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/227:45 PM Western Kentucky 8-2 92% +22½ -114FanDuel
LSU 6-4 8% -21½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/228:00 PM #11Brigham Young 9-1 62% -2½ -114FanDuel
Cincinnati 7-3 38% +3 -113Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/228:00 PM #25Arizona State 7-3 15% -7 -110Caesars
Colorado 3-7 85% +7½ -115Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2210:30 PM Washington 7-3 13% -10½ -105FanDuel
UCLA 3-7 87% +10½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2210:30 PM San Jose State 3-7 89% +12½ -110Bet365
San Diego State 8-2 11% -11½ -114FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2210:30 PM Utah State 5-5 83% +2½ -104Caesars
Fresno State 7-3 17% -2½ -115Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. FINALTUE 11/187:00 PM Massachusetts 0-11 14 +34½ -115BetMGM
Ohio 7-4 42 -33½ -115BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. FINALTUE 11/187:00 PM Akron 5-7 19 +3 -114BetRivers
Bowling Green 3-8 16 -2½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. FINALTUE 11/187:00 PM Western Michigan 7-4 35 -6 -115Bet365
Northern Illinois 3-8 19 +7½ -122FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. FINALWED 11/197:00 PM Miami (OH) 6-5 37 -1½ -120BetMGM
Buffalo 5-6 20 +2½ -107Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. FINALWED 11/197:00 PM Central Michigan 7-4 28 -7½ -110Bet365
Kent State 4-7 16 +8½ -115FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. FINALTHU 11/207:30 PM Louisiana 5-6 34 +3 -120BetRivers
Arkansas State 5-6 30 -2½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. FINALFRI 11/218:00 PM Florida State 5-6 11 -6½ -114FanDuel
North Carolina State 6-5 21 +7 -118SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. FINALFRI 11/2110:30 PM Hawaii 7-4 10 +2½ -105BetMGM
UNLV 9-2 38 -2 -121SugarHouse

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