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The upcoming Saturday football clash on December 6, 2025, between the Indiana Hoosiers and Ohio State Buckeyes at Lucas Oil Stadium in Indianapolis, IN, promises an exciting matchup in the 2025-26 NCAAF season. This game offers bettors a great opportunity to analyze the latest odds and betting lines to make informed wagers. The current point spread favors the Ohio State Buckeyes at -5½ -110, showing a slight shift from the opening odds, indicating growing confidence in the Buckeyes' ability to cover the spread. Indiana Hoosiers are the underdogs with a +5½ -109 spread, providing a favorable risk-reward scenario for bettors seeking value on the Hoosiers. The total over/under is set at 48½ -110, reflecting expectations of a moderately high-scoring game at this iconic venue.
Broadcast live on FOX, this game is a must-watch for fans and bettors alike. Understanding the betting odds and point spread helps bettors gauge potential outcomes and maximize their returns. For the best betting experience, consider checking out the latest NCAAF odds to stay updated on shifts and trends. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.
![]() Jacksonville State 8-429% -1½ -103Caesars | |||||||
![]() James Madison 11-150% -21½ -114FanDuel | |||||||
#24Tulane 10-254% +2½ -105BetMGM | |||||||
![]() Boise State 8-4100% -3½ -105Bet365 | |||||||
![]() #5Texas Tech 11-139% -13 -110Bet365 | |||||||
![]() Western Michigan 8-425% -2½ -110Bet365 | |||||||
#10Alabama 10-252% +2½ -104FanDuel | |||||||
![]() #18Virginia 10-228% -2½ -122FanDuel | |||||||
![]() #1Ohio State 12-064% -5½ -110Caesars |
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