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The upcoming clash on November 22, 2025, between the Kentucky Wildcats and Vanderbilt Commodores at FirstBank Stadium in Nashville, TN, promises an exciting showdown in the 2025-26 NCAAF season. This Saturday football matchup will be broadcast on ESPN, providing fans and bettors alike a prime viewing opportunity.
Our picks for this game lean towards Vanderbilt to cover the spread of -9.5, with a predicted score of Vanderbilt 31 to Kentucky 25. The total points are expected to go over 53.5, with a predicted total score of 55.75, indicating a game with plenty of offensive action. This prediction is supported by our model's strong hit rate and EV in the point spread market, which has been profitable in recent games, winning 6 of the last 10 bets and showing a positive expected value.
Both teams have shown varying results in recent matches, but Vanderbilt's home advantage at FirstBank Stadium and their robust performance give them the edge in this contest. Kentucky's Wildcats will be looking to upset the home team, making this game a must-watch and a great opportunity for bettors to capitalize on well-informed picks and betting tips.
For more in-depth analysis and to explore additional NCAAF picks, check out our NCAAF picks and predictions. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.
![]() Ohio 6-423% -33 -110Bet365 | |||||||
Bowling Green 3-748% -2½ -118FanDuel | |||||||
![]() Northern Illinois 3-757% +7 -117BetRivers | |||||||
Buffalo 5-550% +1½ -110Bet365 | |||||||
![]() Kent State 4-681% +9½ -105Bet365 | |||||||
Arkansas State 5-50% -2½ -117Caesars | |||||||
![]() North Carolina State 5-564% +5 -118BetRivers | |||||||
UNLV 8-211% -2½ -110FanDuel | |||||||
![]() #1Ohio State 10-040% -30½ -114FanDuel | |||||||
Army 5-450% -9½ -120FanDuel | |||||||
![]() Wake Forest 7-318% -17 -109BetRivers | |||||||
Virginia Tech 3-775% +18 -117SugarHouse | |||||||
![]() #11Oklahoma 8-236% -7½ -105BetMGM | |||||||
SMU 7-313% -2½ -124FanDuel | |||||||
![]() Iowa State 6-40% -4 -114BetRivers | |||||||
![]() Northwestern 5-50% -3½ -110Bet365 | |||||||
#3Texas A&M 10-0- - | |||||||
![]() #5Georgia 9-155% -43½ -115FanDuel | |||||||
![]() Georgia Southern 5-567% +12½ -110Bet365 | |||||||
![]() James Madison 9-122% -12½ -115FanDuel | |||||||
![]() Arizona 7-314% -6½ -110Bet365 | |||||||
![]() Toledo 6-450% -27 -110BetRivers | |||||||
Wyoming 4-60% -6½ -110Bet365 | |||||||
![]() Kennesaw State 7-317% -6½ -105FanDuel | |||||||
#4Alabama 8-2- - | |||||||
Auburn 4-6- - | |||||||
Appalachian State 4-686% +4½ -109Caesars | |||||||
![]() Florida Atlantic 4-683% +7½ -115Bet365 | |||||||
![]() UTEP 2-840% -3 -110Bet365 | |||||||
![]() Middle Tennessee 1-917% -6½ -115BetMGM | |||||||
![]() Louisiana Tech 5-50% +1½ -118FanDuel | |||||||
UAB 3-775% +21½ -109Caesars | |||||||
![]() North Carolina 4-689% +7 -114BetRivers | |||||||
![]() #10Texas 7-310% -8½ -110FanDuel | |||||||
![]() #8Oregon 9-141% -9½ -115BetMGM | |||||||
#21Iowa 6-422% -16½ -110Bet365 | |||||||
![]() UTSA 5-5100% +2½ -105BetMGM | |||||||
![]() #14Vanderbilt 8-218% -8½ -118SugarHouse | |||||||
![]() South Alabama 3-7100% +2½ -110FanDuel | |||||||
![]() Florida International 5-50% +1½ -120BetMGM | |||||||
#9Notre Dame 8-233% -35 -110Bet365 | |||||||
Temple 5-587% +8½ -113BetRivers | |||||||
UCF 4-640% -14 -105BetMGM | |||||||
Maryland 4-6100% +13½ -105BetMGM | |||||||
![]() Houston 8-20% -1 -114BetRivers | |||||||
![]() #13Utah 8-210% -17 -120Bet365 | |||||||
Troy 6-433% -11 -110Bet365 | |||||||
![]() South Carolina 3-725% -23½ -110FanDuel | |||||||
![]() Clemson 5-5- - | |||||||
Texas State 4-6- -17½ -110Bet365 | |||||||
![]() #16Georgia Tech 9-16% -2½ -110Bet365 | |||||||
![]() Penn State 4-625% -9½ -110Caesars | |||||||
![]() Boise State 6-40% -16½ -110Bet365 | |||||||
Air Force 3-7100% +3½ -114Caesars | |||||||
Florida 3-782% +5 -120BetRivers | |||||||
Stanford 3-791% +3 -109Caesars | |||||||
![]() Wisconsin 3-7100% +8½ -105FanDuel | |||||||
Rice 5-560% +18½ -110Bet365 | |||||||
LSU 6-433% -21½ -110Bet365 | |||||||
![]() #25Cincinnati 7-395% +3 -122SugarHouse | |||||||
![]() Colorado 3-789% +7½ -115Bet365 | |||||||
UCLA 3-775% +10½ -108Caesars | |||||||
San Diego State 8-20% -11½ -110BetMGM | |||||||
![]() Fresno State 7-30% -2½ -113SugarHouse |
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