Sep 27, 2025 12:00 PM EDT

Week 5

Louisville

2-1

Pittsburgh

LOU

-3½ (-105)o56½ (-110)

ESPN2, 209, ESPN Networks

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Louisville Cardinals vs Pittsburgh Panthers Injury Report

Updated:Sep 22, 2025 6:19 AM EDT

As the Louisville Cardinals prepare to take on the Pittsburgh Panthers on September 27, 2025, at Acrisure Stadium in Pittsburgh, PA, the injury report plays a critical role in shaping betting decisions. With the game airing on ESPN2, fans and bettors alike are keen to understand the implications of player injuries. For Louisville, running back Duke Watson is probable to play, while Isaac Brown remains questionable. The offensive line will miss Trevonte Sylvester, out until September 5, 2025, and linebacker Stanquan Clark, sidelined until November 29, 2025. Tight end Grant Houser is out for the season. Chris Bell, a wide receiver, is expected to play. Meanwhile, Pittsburgh faces challenges with key players like Rashad Battle and Tamon Lynum, both defensive backs, out for this clash. Linebacker Davin Brewton and defensive linemen Jaeden Moore and Denim Cook are also out. Tight end Jake Overman is questionable, with plans to transfer. This injury landscape could tilt the game in Louisville's favor. Bettors should consider these player statuses when placing bets and can find detailed updates on the NCAAF injury page. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.

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NCAAF

ODDS PICKS PLAYER PROPS FUTURES PLAYER FUTURES INJURIES WEATHER RANKINGS STANDINGS

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NCAAF Thu 09/25

Personalize your notifications and get updates on the teams, players or events you care about most. THU 09/257:30 PM Army 1-2 33% +3½ -110Caesars
East Carolina 2-2 67% -3½ -105BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. FRI 09/267:00 PM #8Florida State 3-0 11% -6½ -122FanDuel
Virginia 3-1 89% +7 -110BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. FRI 09/269:00 PM #24TCU 3-0 20% +2½ -110Caesars
Arizona State 3-1 80% -2½ -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. FRI 09/2610:30 PM Houston 3-0 0% -11½ -110FanDuel
Oregon State 0-4 100% +12½ -110BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/2712:00 PM Bowling Green 2-2 100% +10½ -105FanDuel
Ohio 2-2 0% -10½ -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/2712:00 PM #22Notre Dame 1-2 25% -5½ -112FanDuel
Arkansas 2-2 75% +6 -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/2712:00 PM Louisville 3-0 33% -3 -115Caesars
Pittsburgh 2-1 67% +3½ -110FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/2712:00 PM Duke 2-2 50% -5½ -110Caesars
Syracuse 3-1 50% +5½ -105FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/2712:00 PM #16Georgia Tech 4-0 0% -14½ -110Caesars
Wake Forest 2-1 100% +15½ -115FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/2712:00 PM Rutgers 3-1 0% +5½ -110FanDuel
Minnesota 2-1 100% -5½ -110FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/2712:00 PM Cincinnati 2-1 83% +6½ -120FanDuel
Kansas 3-1 17% -6 -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/2712:00 PM South Alabama 1-3 100% +13½ -110BetMGM
North Texas 4-0 0% -12½ -115FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/2712:00 PM UCF 3-0 13% +6 -110Caesars
Kansas State 1-3 87% -5½ -115FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/2712:00 PM #21USC 4-0 28% -6½ -110Caesars
#23Illinois 3-1 72% +6½ -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/2712:45 PM Utah State 3-1 100% +22½ -110Caesars
#18Vanderbilt 4-0 0% -22½ -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/271:00 PM Eastern Michigan 1-3 100% +6½ -112BetRivers
Central Michigan 2-2 0% -5½ -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/271:30 PM Georgia Southern 2-2 75% +16½ -110Caesars
James Madison 2-1 25% -15½ -110FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/273:00 PM Arkansas State 1-3 - +3½ -115FanDuel
Louisiana-Monroe 2-1 - -3 -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/273:30 PM Akron 1-3 - +21½ -115BetMGM
Toledo 2-2 - -20½ -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/273:30 PM Utah 3-1 0% -10½ -109BetRivers
West Virginia 2-2 100% +11½ -118FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/273:30 PM San Diego State 2-1 0% -3 -105BetMGM
Northern Illinois 1-2 100% +3½ -124FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/273:30 PM California 3-1 60% +6½ -105Caesars
Boston College 1-2 40% -6 -113BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/273:30 PM Connecticut 2-2 - -2½ -114BetRivers
Buffalo 2-2 - +3 -115Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/273:30 PM #11Indiana 4-0 33% -6½ -122FanDuel
Iowa 3-1 67% +7 -105Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/273:30 PM UCLA 0-3 - +6½ -105FanDuel
Northwestern 1-2 - -6½ -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/273:30 PM Rice 3-1 0% +14½ -110Caesars
Navy 3-0 100% -14½ -108BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/273:30 PM Baylor 2-2 - -19½ -110FanDuel
Oklahoma State 1-2 - +20½ -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/273:30 PM #4LSU 4-0 71% +1½ -102FanDuel
#13Ole Miss 4-0 29% -1½ -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/273:30 PM Auburn 3-1 100% +6½ -106FanDuel
#9Texas A&M 3-0 0% -6½ -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/273:30 PM #1Ohio State 3-0 13% -8½ -108FanDuel
Washington 3-0 87% +9½ -108BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/273:30 PM Lindenwood University 2-2 - -
Miami (OH) 0-3 - -
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/274:00 PM Hawaii 3-2 - +4½ -110Caesars
Air Force 1-2 - -4½ -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/274:00 PM New Mexico State 2-1 - +14 -110Caesars
New Mexico 2-1 - -13½ -110BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/274:00 PM Tulane 3-1 - -12½ -110FanDuel
Tulsa 2-2 - +13½ -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/274:15 PM #15Tennessee 3-1 0% -7½ -105Caesars
Mississippi State 4-0 100% +8½ -110FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/276:00 PM Liberty 1-3 0% +16 -110Caesars
Old Dominion 2-1 100% -15½ -110BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/276:00 PM Middle Tennessee 1-3 - +7 -115Caesars
Kennesaw State 2-2 - -6½ -112BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/276:30 PM Rhode Island 4-0 - -
Western Michigan 1-3 - -
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/277:00 PM Memphis 4-0 0% -13½ -110Caesars
Florida Atlantic 1-2 100% +13½ -105FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/277:00 PM Virginia Tech 1-3 100% +10½ -110Caesars
North Carolina State 3-1 0% -10½ -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/277:00 PM Jacksonville State 2-2 - +3½ -105FanDuel
Southern Miss 2-2 - -3½ -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/277:00 PM Arizona 3-0 75% +6½ -106FanDuel
#14Iowa State 4-0 25% -6 -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/277:00 PM Western Kentucky 3-1 - -5½ -110Caesars
Missouri State 2-2 - +5½ -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/277:30 PM Appalachian State 2-1 0% +17½ -110BetMGM
Boise State 2-1 100% -17½ -105Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/277:30 PM San Jose State 1-2 0% +2 -110Caesars
Stanford 1-3 100% -1½ -110BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/277:30 PM Massachusetts 0-3 - +43½ -110FanDuel
#20Missouri 4-0 - -42½ -110BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/277:30 PM Washington State 2-2 - +4½ -105FanDuel
Colorado State 1-2 - -4½ -109BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/277:30 PM #6Oregon 4-0 8% +3½ -110Caesars
#3Penn State 3-0 92% -3½ -105FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/277:30 PM #17Alabama 2-1 67% +3½ -120FanDuel
#5Georgia 3-0 33% -3 -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/277:45 PM Kentucky 2-1 67% +6½ -109BetRivers
South Carolina 2-2 33% -6½ -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/278:00 PM Marshall 2-2 - +2½ -105FanDuel
Louisiana 1-3 - -2½ -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/279:00 PM Louisiana Tech 3-1 0% -3½ -109BetRivers
UTEP 1-3 100% +4 -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/2710:15 PM #25Brigham Young 3-0 40% -6½ -110Caesars
Colorado 2-2 60% +6½ -110Caesars

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Louisville Cardinals vs Pittsburgh Panthers Injury Report

Injuries

Louisville

Pittsburgh