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Before the anticipated clash on September 27, 2025, between the Louisville Cardinals and the Pittsburgh Panthers at Acrisure Stadium in Pittsburgh, PA, football fans are buzzing with excitement. This matchup, part of the NCAAF's Week 5, promises to be a thrilling Saturday football event. The Cardinals, having shown a strong performance in previous games, are predicted to edge out the Panthers with a close score of 29-28. Our prediction model indicates a profitable trend with a 54.5% hit rate for Louisville in the 2way market. Bettors might find value in exploring the point spread, with Pittsburgh's +3.5 showing a slight edge with a 55.2% coverage percentage. The game will be broadcasted on ESPN2, making it accessible for fans and bettors alike. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge. Don't forget to check our detailed NCAAF picks page for more insights and predictions.
East Carolina 2-267% -3 -113BetRivers | |||||||
![]() Virginia 3-189% +7 -110BetMGM | |||||||
![]() Arizona State 3-180% -2½ -110Caesars | |||||||
![]() Oregon State 0-4100% +12½ -110BetMGM | |||||||
![]() Ohio 2-20% -10½ -110Caesars | |||||||
![]() Arkansas 2-275% +6 -110Caesars | |||||||
![]() Pittsburgh 2-167% +3½ -110FanDuel | |||||||
Syracuse 3-150% +5½ -105FanDuel | |||||||
![]() Wake Forest 2-1100% +15½ -115FanDuel | |||||||
Minnesota 2-1100% -5½ -110FanDuel | |||||||
![]() Kansas 3-117% -6 -110Caesars | |||||||
![]() North Texas 4-00% -12½ -115FanDuel | |||||||
![]() Kansas State 1-387% -5½ -115FanDuel | |||||||
#23Illinois 3-172% +6½ -110Caesars | |||||||
![]() #18Vanderbilt 4-00% -22½ -110Caesars | |||||||
Central Michigan 2-20% -5½ -110Caesars | |||||||
![]() James Madison 2-125% -15½ -110FanDuel | |||||||
![]() Louisiana-Monroe 2-1- -3 -110Caesars | |||||||
![]() Toledo 2-2- -20½ -110Caesars | |||||||
West Virginia 2-2100% +11½ -118FanDuel | |||||||
![]() Northern Illinois 1-2100% +3½ -124FanDuel | |||||||
![]() Boston College 1-240% -6 -113BetRivers | |||||||
Buffalo 2-2- +3 -115Caesars | |||||||
Iowa 3-167% +7 -105Caesars | |||||||
![]() Northwestern 1-2- -6½ -110Caesars | |||||||
Navy 3-0100% -14½ -108BetRivers | |||||||
Oklahoma State 1-2- +20½ -110Caesars | |||||||
![]() #13Ole Miss 4-029% -1½ -110Caesars | |||||||
#9Texas A&M 3-00% -6½ -110Caesars | |||||||
![]() Washington 3-087% +9½ -108BetRivers | |||||||
Miami (OH) 0-3- - | |||||||
Air Force 1-2- -4½ -110Caesars | |||||||
![]() New Mexico 2-1- -13½ -110BetRivers | |||||||
![]() Tulsa 2-2- +13½ -110Caesars | |||||||
![]() Mississippi State 4-0100% +9½ -112BetRivers | |||||||
![]() Old Dominion 2-1100% -15½ -110Caesars | |||||||
![]() Kennesaw State 2-2- -6½ -112BetRivers | |||||||
![]() Western Michigan 1-3- - | |||||||
![]() Florida Atlantic 1-2100% +13½ -105FanDuel | |||||||
![]() North Carolina State 3-10% -10½ -110Caesars | |||||||
Southern Miss 2-2- -3½ -110Caesars | |||||||
![]() #14Iowa State 4-025% -6 -110Caesars | |||||||
![]() Missouri State 2-2- +5½ -110Caesars | |||||||
![]() Boise State 2-1100% -17½ -105Caesars | |||||||
Stanford 1-3100% -1½ -110BetMGM | |||||||
![]() #20Missouri 4-0- -42½ -110BetMGM | |||||||
![]() Colorado State 1-2- -4½ -109BetRivers | |||||||
![]() #3Penn State 3-092% -3½ -105FanDuel | |||||||
![]() #5Georgia 3-033% -3 -110Caesars | |||||||
![]() South Carolina 2-233% -6½ -110Caesars | |||||||
![]() Louisiana 1-3- -2½ -110Caesars | |||||||
![]() UTEP 1-3100% +4 -110Caesars | |||||||
![]() Colorado 2-260% +6½ -110Caesars |
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