Nov 22, 2025 12:00 PM EST

Week 13

Louisville

7-3

SMU

-3 (-107)o51½ (-112)

ESPN2, 209

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Louisville Cardinals vs SMU Mustangs Picks

Updated:Nov 21, 2025 2:23 AM EST

The upcoming Saturday football game on November 22, 2025, features a thrilling NCAAF match between the Louisville Cardinals and the SMU Mustangs at Gerald J. Ford Stadium in Dallas, TX. This game will be broadcasted on ESPN2, providing fans and bettors a prime viewing experience. Our expert picks have the SMU Mustangs edging out the Louisville Cardinals with a predicted final score of 29-25, favoring SMU by 2.5 points on the spread. The total points are expected to go over 52.5, with a predicted total score of approximately 53.3.

Our prediction model has been profitable recently, boasting a hit rate of 55.1% on the SMU spread market and an EV of 2.7%, making it a strong choice for bettors seeking value. Additionally, the over 52.5 points market has a positive EV and a cover percentage near 52.5%, indicating solid potential for bettors interested in totals. These stats provide valuable insights that can help fans make smarter betting decisions for this exciting NCAAF showdown.

For more detailed analysis and additional picks, check out our comprehensive NCAAF picks and predictions. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook to capitalize on these insights.

Which team is favored in the picks for this game?

NCAAF

ODDS PICKS PLAYER PROPS FUTURES PLAYER FUTURES INJURIES WEATHER RANKINGS STANDINGS

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NCAAF Fri 11/21

Personalize your notifications and get updates on the teams, players or events you care about most. FRI 11/218:00 PM Florida State 5-5 56% -5½ -110BetMGM
North Carolina State 5-5 44% +6 -108Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. FRI 11/2110:30 PM Hawaii 7-3 59% +3 -110Bet365
UNLV 8-2 41% -2 -129SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:00 PM Rutgers 5-5 70% +32½ -110BetRivers
#1Ohio State 10-0 30% -31½ -110FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:00 PM Tulsa 3-7 64% +10 -105BetMGM
Army 5-4 36% -9½ -120FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:00 PM Delaware 5-5 70% +17½ -108FanDuel
Wake Forest 7-3 30% -17½ -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:00 PM #13Miami (FL) 8-2 38% -17½ -110Bet365
Virginia Tech 3-7 62% +18½ -113BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:00 PM #22Missouri 7-3 66% +7 -110BetMGM
#8Oklahoma 8-2 34% -6½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:00 PM Louisville 7-3 76% +3 -113Caesars
SMU 7-3 24% -2½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:00 PM Kansas 5-5 65% +3½ -105BetMGM
Iowa State 6-4 35% -3½ -108Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:00 PM Minnesota 6-4 61% +4 -118BetRivers
Northwestern 5-5 39% -3½ -110BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:00 PM Samford 1-10 - +55½ -110FanDuel
#3Texas A&M 10-0 - -54½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2212:45 PM Charlotte 1-9 52% +44 -114BetRivers
#4Georgia 9-1 48% -43½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/221:00 PM Old Dominion 7-3 44% -10½ -110Bet365
Georgia Southern 5-5 56% +12½ -115BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/221:00 PM Washington State 5-5 69% +14 -113BetRivers
James Madison 9-1 31% -13½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/221:00 PM Baylor 5-5 70% +7 -114Caesars
Arizona 7-3 30% -6½ -120FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/222:00 PM Ball State 4-6 13% +28½ -122FanDuel
Toledo 6-4 87% -27½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/222:00 PM Nevada 2-8 90% +7½ -120FanDuel
Wyoming 4-6 10% -6½ -112Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/222:00 PM Missouri State 7-3 78% +6½ -110BetMGM
Kennesaw State 7-3 22% -6½ -105FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/222:00 PM Mercer 9-1 - +27½ -110Bet365
Auburn 4-6 - -27½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/222:00 PM Eastern Illinois 3-8 - +50½ -110FanDuel
#10Alabama 8-2 - -50½ -110FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/222:30 PM Marshall 5-5 36% -4½ -114BetRivers
Appalachian State 4-6 64% +5½ -114Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:00 PM Connecticut 8-3 12% -7 -110Caesars
Florida Atlantic 4-6 88% +7½ -120FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:00 PM New Mexico State 3-7 75% +3½ -117BetRivers
UTEP 2-8 25% -3 -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:00 PM Sam Houston State 2-8 60% +6½ -104Caesars
Middle Tennessee 1-9 40% -6½ -113BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:00 PM Liberty 4-6 70% +1½ -125BetMGM
Louisiana Tech 5-5 30% +1½ -117SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:00 PM South Florida 7-3 28% -21½ -108FanDuel
UAB 3-7 72% +21½ -109Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:30 PM Duke 5-5 18% -6½ -120FanDuel
North Carolina 4-6 82% +7 -113Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:30 PM Arkansas 2-8 85% +9 -110Bet365
#17Texas 7-3 15% -8½ -110FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:30 PM #15USC 8-2 54% +10 -110Bet365
#7Oregon 9-1 46% -9½ -118SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:30 PM Michigan State 3-7 71% +17 -110Caesars
Iowa 6-4 29% -16½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:30 PM East Carolina 7-3 19% -2½ -110Bet365
UTSA 5-5 81% +2½ -108Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:30 PM Kentucky 5-5 89% +9½ -110Bet365
#14Vanderbilt 8-2 11% -8½ -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:30 PM Southern Miss 7-3 46% -1½ -107Caesars
South Alabama 3-7 54% +2½ -110FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:30 PM Jacksonville State 7-3 14% +½ -110SugarHouse
Florida International 5-5 86% +1½ -120Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:30 PM Syracuse 3-7 33% +36 -110Caesars
#9Notre Dame 8-2 67% -35 -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/223:45 PM #24Tulane 8-2 22% -7½ -115FanDuel
Temple 5-5 78% +9½ -112Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/224:00 PM Oklahoma State 1-9 77% +14 -110Bet365
UCF 4-6 23% -13 -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/224:00 PM #18Michigan 8-2 27% -13½ -120FanDuel
Maryland 4-6 73% +14 -107Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/224:00 PM TCU 6-4 57% +2 -110Bet365
#23Houston 8-2 43% -1 -114BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/224:00 PM Kansas State 5-5 74% +17½ -110BetMGM
#12Utah 8-2 26% -17 -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/224:00 PM Georgia State 1-9 57% +10½ -110Bet365
Troy 6-4 43% -10 -110BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/224:15 PM Coastal Carolina 6-4 70% +24 -108Caesars
South Carolina 3-7 30% -23½ -122FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/224:30 PM Furman 6-5 - +41½ -110FanDuel
Clemson 5-5 - -41½ -110FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/225:00 PM Louisiana-Monroe 3-7 33% +19½ -110Bet365
Texas State 4-6 67% -18 -113BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/227:00 PM Pittsburgh 7-3 92% +3 -117BetRivers
#16Georgia Tech 9-1 8% -2½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/227:00 PM Nebraska 7-3 63% +9½ -104FanDuel
Penn State 4-6 37% -8 -112Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/227:00 PM Colorado State 2-8 100% +17½ -115BetMGM
Boise State 6-4 0% -16½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/227:00 PM New Mexico 7-3 8% -3½ -102FanDuel
Air Force 3-7 92% +4 -118SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/227:30 PM #20Tennessee 7-3 19% -3½ -118FanDuel
Florida 3-7 81% +4½ -115BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/227:30 PM California 6-4 17% -2½ -120FanDuel
Stanford 3-7 83% +3½ -114Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/227:30 PM #21Illinois 7-3 12% -8 -114BetRivers
Wisconsin 3-7 88% +8½ -110BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/227:30 PM North Texas 9-1 20% -17½ -115BetMGM
Rice 5-5 80% +18½ -114BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/227:45 PM Western Kentucky 8-2 69% +22 -112Caesars
LSU 6-4 31% -21½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/228:00 PM #11Brigham Young 9-1 14% -2 -110Bet365
Cincinnati 7-3 86% +2½ -105Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/228:00 PM #25Arizona State 7-3 13% -7 -110Caesars
Colorado 3-7 87% +7½ -114FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2210:30 PM Washington 7-3 15% -10½ -109Caesars
UCLA 3-7 85% +10½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2210:30 PM San Jose State 3-7 88% +12½ -110BetMGM
San Diego State 8-2 12% -12 -115SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 11/2210:30 PM Utah State 5-5 100% +3 -113BetRivers
Fresno State 7-3 0% -2½ -115Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. FINALTUE 11/187:00 PM Massachusetts 0-11 14 +34½ -115BetMGM
Ohio 7-4 42 -33½ -115BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. FINALTUE 11/187:00 PM Akron 5-7 19 +3 -114BetRivers
Bowling Green 3-8 16 -2½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. FINALTUE 11/187:00 PM Western Michigan 7-4 35 -6 -115Bet365
Northern Illinois 3-8 19 +7½ -122FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. FINALWED 11/197:00 PM Miami (OH) 6-5 37 -1½ -120BetMGM
Buffalo 5-6 20 +2½ -107Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. FINALWED 11/197:00 PM Central Michigan 7-4 28 -7½ -110Bet365
Kent State 4-7 16 +8½ -115FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. FINALTHU 11/207:30 PM Louisiana 5-6 34 +3 -120BetRivers
Arkansas State 5-6 30 -2½ -110Bet365

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