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As we gear up for the October 18, 2025, showdown between the Northwestern Wildcats and Purdue Boilermakers, football fans and bettors alike are in for a thrilling Saturday football experience. Taking place at Northwestern Medicine Field at Martin Stadium in Evanston, IL, this NCAAF matchup promises to be a clash of strategies and skills. Northwestern, with a solid record of 4-2-0 straight up, will look to leverage their formidable pass offense, which averages 181.3 passing yards per game, against Purdue's shaky pass defense that allows 245.7 yards on average.
Purdue, on the other hand, is eager to bounce back from recent defeats and improve their 2-4-0 record. Their offensive line will need to step up to protect their quarterback against Northwestern's aggressive pass rush. With Northwestern having won the last matchup on November 2, 2024, by 26-20, they have a psychological edge. The Wildcats' defense, known for forcing turnovers, will be crucial in disrupting Purdue's rhythm.
The betting odds favor Northwestern with a -3.5 point spread at Caesars. For those looking to place a smart bet, consider the Wildcats' strong performance at home, reflected in their 3-1 home ATS record. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge. Catch the action live on BTN and make informed bets based on these betting trends and game insights.
![]() Liberty 2-417% -10½ -105BetMGM | |||||||
![]() South Alabama 1-543% -6½ -122FanDuel | |||||||
![]() Western Kentucky 5-137% -7½ -110Caesars | |||||||
![]() Jacksonville State 3-367% +2½ -112FanDuel | |||||||
![]() Sam Houston State 0-660% +2½ +100Caesars | |||||||
East Carolina 3-333% -16½ -110Caesars | |||||||
![]() #2Miami (FL) 5-023% -12½ -115FanDuel | |||||||
Minnesota 4-287% +6½ -110Caesars | |||||||
![]() Utah State 3-350% -4 -110Caesars | |||||||
![]() California 4-20% -10½ -110Caesars | |||||||
Miami (OH) 3-30% -12½ -110FanDuel | |||||||
![]() Boston College 1-550% -1½ -110Caesars | |||||||
![]() Duke 4-257% -2½ -115BetMGM | |||||||
Bowling Green 3-3- -5½ -110FanDuel | |||||||
![]() #17Vanderbilt 5-167% -2½ -110Caesars | |||||||
![]() Michigan 4-250% -5½ -106FanDuel | |||||||
![]() Houston 5-133% -1½ -108FanDuel | |||||||
TCU 4-225% -2½ -120FanDuel | |||||||
![]() Tulane 5-133% -10½ -110Caesars | |||||||
![]() South Carolina 3-3100% +5½ -110Caesars | |||||||
UCF 3-350% -7 -110Caesars | |||||||
![]() Toledo 3-3- -24½ -110BetRivers | |||||||
![]() Massachusetts 0-6100% +17½ -115Caesars | |||||||
![]() Louisiana-Monroe 3-3- +6½ -110BetRivers | |||||||
![]() Northwestern 4-20% -3½ -110Caesars | |||||||
Appalachian State 4-2- -11½ -110Caesars | |||||||
![]() Ohio 3-3- -11½ -115BetMGM | |||||||
![]() James Madison 5-10% -2 -110Caesars | |||||||
![]() Charlotte 1-5- +12½ -110FanDuel | |||||||
![]() Clemson 3-333% -9½ -110Caesars | |||||||
![]() #3Indiana 6-020% -26½ -113BetRivers | |||||||
Marshall 3-360% +3½ -113BetRivers | |||||||
Ball State 2-4- -1½ -105FanDuel | |||||||
![]() Boise State 4-267% -10½ -110Caesars | |||||||
![]() North Texas 5-150% -5½ -110Caesars | |||||||
![]() #9Georgia 5-143% -6½ -105BetMGM | |||||||
![]() Arkansas 2-464% +7½ -110Caesars | |||||||
![]() Wisconsin 2-471% +27½ -110Caesars | |||||||
Air Force 1-50% -4½ -115FanDuel | |||||||
UAB 2-4100% +21½ -110BetMGM | |||||||
![]() Arizona State 4-289% +10½ -110Caesars | |||||||
Florida 2-4100% -9½ -112BetRivers | |||||||
![]() Louisiana 2-4- +4 -110Caesars | |||||||
![]() #18Virginia 5-10% -17½ -104FanDuel | |||||||
Rutgers 3-3100% +15½ -110BetRivers | |||||||
![]() Georgia Southern 2-40% -6½ -113BetRivers | |||||||
![]() Colorado State 2-4100% +1 -117BetRivers | |||||||
UCLA 2-450% -2½ -118FanDuel | |||||||
Iowa 4-250% -2½ -118FanDuel | |||||||
Kentucky 2-350% +12½ -115BetMGM | |||||||
![]() #19South Florida 5-1- -21½ -110BetMGM | |||||||
Syracuse 3-3- +11½ -110Caesars | |||||||
#13Notre Dame 4-244% -7½ -110FanDuel | |||||||
#6Alabama 5-133% -8 -110Caesars | |||||||
Auburn 3-375% -1½ -110BetRivers | |||||||
Oklahoma State 1-5100% +21½ -112BetRivers | |||||||
#15Brigham Young 6-00% +3½ -120FanDuel | |||||||
![]() New Mexico 3-30% -10 -110BetRivers | |||||||
![]() Oregon State 0-7- - | |||||||
Stanford 2-4- +17½ -110Caesars |
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