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The Pittsburgh Panthers vs Syracuse Orange clash on Saturday, October 18, 2025, marks a key Saturday football showdown in NCAAF. Kickoff at JMA Wireless Dome in Syracuse, NY, airs on ACC Network. This matchup sets the stage for intriguing betting trends and betting insights heading into Week 8.
The Panthers will start their backup quarterback, while the Orange roll with their first-string passer. Pittsburgh’s offense averages 309.3 passing and 122.5 rushing yards per game, facing Syracuse’s defense that yields 291.2 aerial and 157.7 ground yards. Conversely, Syracuse produces 320.5 through the air and 111.8 on the ground against Pittsburgh’s stingier unit allowing 230.2 passing and 82.2 rushing. On the trenches, Pittsburgh allows 2.8 sacks per game versus Syracuse’s rush generating 1.3, while Syracuse concedes 2.5 sacks against a Panthers defense that logs three sacks per contest.
The Panthers enter as 10.5-point favorites (-112) and Syracuse sits at +10.5 (-110) at Caesars, with the total set at 54.5 (Over -118/Under -104). Their 1-1 away ATS record is worth exploring on our NCAAF standings page. In their last meeting on October 24, 2024, Pittsburgh dominated 41-13.
These numbers highlight why monitoring betting trends and leveraging sharp betting insights is crucial. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your wager with a U.S. regulated sportsbook to capitalize on the edge.
East Carolina 3-356% -16½ -110Bet365 | |||||||
![]() #2Miami (FL) 5-050% -13½ -110Caesars | |||||||
Minnesota 4-233% +7½ -102FanDuel | |||||||
![]() Utah State 3-334% -3 -120Caesars | |||||||
![]() California 4-246% -9½ -118BetRivers | |||||||
Miami (OH) 3-330% -12½ -115FanDuel | |||||||
![]() Boston College 1-570% -1½ -110Bet365 | |||||||
![]() Duke 4-277% -1 -115SugarHouse | |||||||
Bowling Green 3-335% -4 -118SugarHouse | |||||||
![]() #17Vanderbilt 5-153% -2½ -110Caesars | |||||||
![]() Michigan 4-258% -5½ -115BetMGM | |||||||
![]() Houston 5-148% +1½ -115BetMGM | |||||||
TCU 4-248% -2½ -122FanDuel | |||||||
![]() Tulane 5-129% -9½ -110Bet365 | |||||||
![]() South Carolina 3-369% +6 -117SugarHouse | |||||||
UCF 3-333% -7 -113BetRivers | |||||||
![]() Toledo 3-340% -26½ -110Caesars | |||||||
![]() Massachusetts 0-675% +17 -110Caesars | |||||||
![]() Louisiana-Monroe 3-373% +6 -110Caesars | |||||||
![]() Northwestern 4-245% -3 -113Caesars | |||||||
Appalachian State 4-20% -10 -110Bet365 | |||||||
![]() Ohio 3-30% -10½ -113BetRivers | |||||||
![]() James Madison 5-133% -1 -114BetRivers | |||||||
![]() Charlotte 1-556% +11½ -110Caesars | |||||||
![]() Clemson 3-345% -8½ -112BetRivers | |||||||
![]() #3Indiana 6-029% -27 -112BetRivers | |||||||
Marshall 3-365% +3 -115BetMGM | |||||||
Ball State 2-420% -1 -110Caesars | |||||||
![]() Boise State 4-278% -12 -113BetRivers | |||||||
![]() North Texas 5-133% -3½ -115FanDuel | |||||||
![]() #9Georgia 5-163% -7½ -105BetMGM | |||||||
![]() Arkansas 2-481% +7½ -105FanDuel | |||||||
![]() Wisconsin 2-495% +26 -113BetRivers | |||||||
Air Force 1-520% -4 -112Caesars | |||||||
UAB 2-421% +21½ -110Caesars | |||||||
![]() Arizona State 4-236% +7½ -110Caesars | |||||||
Florida 2-443% -8½ -114SugarHouse | |||||||
![]() Louisiana 2-460% +3½ -108FanDuel | |||||||
![]() #18Virginia 5-122% -16½ -117SugarHouse | |||||||
Rutgers 3-381% +17½ -117BetRivers | |||||||
![]() Georgia Southern 2-48% -6½ -110Bet365 | |||||||
![]() Colorado State 2-457% -2½ -110Bet365 | |||||||
UCLA 2-437% -3 -120SugarHouse | |||||||
Iowa 4-281% -2½ -115FanDuel | |||||||
Kentucky 2-367% +12½ -105FanDuel | |||||||
![]() #19South Florida 5-114% -21½ -110Caesars | |||||||
Syracuse 3-340% +11½ -114SugarHouse | |||||||
#13Notre Dame 4-261% -9 -113SugarHouse | |||||||
#6Alabama 5-133% -8 -110Caesars | |||||||
Auburn 3-364% +2 -115SugarHouse | |||||||
Oklahoma State 1-585% +22½ -117SugarHouse | |||||||
#15Brigham Young 6-070% +4 -115BetRivers | |||||||
![]() New Mexico 3-320% -11½ -110BetMGM | |||||||
![]() Oregon State 0-7- -22½ -110FanDuel | |||||||
Stanford 2-473% +18 -110Bet365 | |||||||
![]() Liberty 3-430 -10½ -108Caesars | |||||||
![]() South Alabama 1-614 -7½ -115BetMGM | |||||||
![]() Western Kentucky 5-26 -10 -110Bet365 | |||||||
![]() Jacksonville State 4-338 +3 -110Caesars | |||||||
![]() Sam Houston State 0-717 +3½ -114FanDuel |
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