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FINAL
Nov 14, 2025 7:30 PM EST
CLEM 20 vs LOU 19
Week 12
LOU
-1½ (-110)o51 (-110)
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Clemson Tigers vs Louisville Cardinals Betting Trends
Updated:Nov 14, 2025 1:52 AM EST
The upcoming Friday football clash on November 14, 2025, between the Louisville Cardinals and Clemson Tigers at L&N Federal Credit Union Stadium in Louisville, KY, promises an exciting showdown in the 2025-26 NCAAF season. The Louisville Cardinals will host the Clemson Tigers with a point spread favoring Louisville by 2.5 points and an under total of 51.5 points, making the betting trends particularly intriguing for bettors.
Louisville's offensive line boasts a strong running game with an average of 154.9 rushing yards per game, while Clemson counters with a stout run defense allowing just 106.2 yards. Clemson's passing offense is robust with 288.4 yards per game, but Louisville's pass defense limits opponents to 188.1 yards, suggesting a strategic battle in the air. Both teams feature strong pass protection and pass rush stats, with Clemson averaging 1.56 sacks allowed per game and Louisville generating 2.11 sacks per game, setting the stage for a dynamic quarterback duel.
Louisville's starting quarterback is healthy and likely to play, while Clemson's quarterback situation looks stable as well. The previous meeting on November 2, 2024, saw Louisville defeat Clemson 33-21 at Memorial Stadium in Clemson, SC, a game that influences current betting insights. Both teams have mixed records against the spread this season, with Louisville struggling at home ATS but showing strength overall. The best odds today favor Louisville at -120 on Caesars sportsbook, with Clemson available at +100.
These betting trends and game insights suggest a competitive game with Louisville holding a slight edge at home. Bettors should consider the impact of rushing versus run defense and the quarterback matchup when placing wagers. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.
In their last matchup on November 2, 2024, where Louisville won 33-21, Louisville showed strong offensive power against Clemson. Check our NCAAF standings page for more ATS records and team stats to inform your bets.
ATS Records
All
5-8 (217th)Against the Spread4-9 (246th)
7-6 (121st)Straight Up9-4 (57th)
-2.7Straight Up Units+1.5
5-8Over / Under6-7
TEAM MATCHUP
OFF
DEF
OFF
DEF
27.2Points29.9
392.2Total Yards384.5
5.6Yards Per Play6
267.8Passing Yards220.6
23.8 - 36.5 (65.1%)Completions-Attempts20.6 - 32.2 (64.1%)
7.3Yards Per Passing Play6.9
11.8Sacks-Yards Lost13.9
124.5Rushing Yards163.9
31.5Attempts32.4
3.9Yards Per Rush5.1
21.11st Downs19.8
11.8Passing9.6
7.5Rushing8.5
1.8Penalties1.7
4.6 / 13.5 (34.3%)3rd Down4.5 / 12.8 (35.3%)
1.5 / 2.8 (55.6%)4th Down0.7 / 1.1 (64.3%)
2.5 / 3.2 (78.6%)Red Zone2.9 / 3.2 (90.5%)
4.4 (42.1)Penalties (Yards)6.9 (63.2)
0.5Interceptions0.7
0.6Fumbles Lost0.6
69.7Total Plays66.5
5.5Kickoffs6.2
1.1Returns1.3
20.5Yards28.3
19Yards Per Return21.6
4.2Punts4.4
1.4Returns2.3
10.1Yards38.5
7.3Yards Per Return16.7
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NCAAF Week 1
NCAAF Sat 08/29
 TCU - -6½ -110Bovada | |||||||
 Valparaiso - - | |||||||
 USC - -35½ -108Heritage | |||||||
 Virginia - -3 -110MyBookie | |||||||
 North Dakota State - -8½ -105BetOnline | |||||||
 Eastern Michigan - -7½ -110Bovada | |||||||
 Florida State - -30½ -108Heritage | |||||||
 Stanford - -3½ -108Heritage | |||||||
 UNLV - -3 -115Bookmaker | |||||||
 Rutgers - -30½ -108Heritage | |||||||
 Wake Forest - -22½ -108Heritage | |||||||
 Kennesaw State - - | |||||||
 Buffalo - - | |||||||
 Delaware - - | |||||||
 UCF - - | |||||||
 Georgia Tech - -7 -110BetOnline | |||||||
 Minnesota - - | |||||||
 Missouri - - | |||||||
 Illinois - -27½ -108Heritage | |||||||
 Utah - - | |||||||
Eastern Michigan - -3½ -108Heritage | |||||||
 Georgia State - - | |||||||
 Purdue - - | |||||||
 Michigan State - -10½ -105BetOnline | |||||||
 Kansas - - | |||||||
USC - -22½ -110BetOnline | |||||||
Stanford - +23 -105BetOnline | |||||||
 West Virginia - -17½ -105BetOnline | |||||||
 James Madison - -6 -110BetOnline | |||||||
 Indiana - -39½ -108Heritage | |||||||
 Alabama - -26½ -108Heritage | |||||||
 Nebraska - -23½ -105BetOnline | |||||||
 Houston - -18½ -108Heritage | |||||||
 Connecticut - - | |||||||
 Syracuse - - | |||||||
 Bowling Green - - | |||||||
 Army - - | |||||||
 Pittsburgh - -15½ -110Bovada | |||||||
 Ohio State - -49½ -110BetOnline | |||||||
 South Carolina - -34½ -108Heritage | |||||||
 Oklahoma - -40½ -105BetOnline | |||||||
 Iowa State - - | |||||||
 Kentucky - - | |||||||
 Air Force - - | |||||||
 Temple - - | |||||||
 Georgia - - | |||||||
 Cincinnati - -7½ -108Heritage | |||||||
 Penn State - -22½ -110BetOnline | |||||||
 Duke - -8 -111Bookmaker | |||||||
 Texas - -30½ -110BetOnline | |||||||
 Oregon - -24½ -108Heritage | |||||||
 Auburn - -7 -105Bookmaker | |||||||
 Tennessee - - | |||||||
 Appalachian State - - | |||||||
 Charlotte - - | |||||||
 UTSA - - | |||||||
North Dakota State - - | |||||||
 Navy - - | |||||||
 Tulsa - +12½ -108Heritage | |||||||
 Iowa - -30 -110Bookmaker | |||||||
 Arkansas - - | |||||||
 Southern Miss - - | |||||||
 Colorado State - -3½ -108Heritage | |||||||
 Old Dominion - - | |||||||
 South Florida - -12 -108Heritage | |||||||
 Texas A&M - -38½ -110BetOnline | |||||||
 Troy - -17 -112Bookmaker | |||||||
 Memphis - -10½ -108Heritage | |||||||
 South Alabama - - | |||||||
 Middle Tennessee - - | |||||||
 Kansas State - - | |||||||
 Utah State - - | |||||||
 Jacksonville State - - | |||||||
 Vanderbilt - - | |||||||
 Georgia Southern - - | |||||||
 Texas Tech - - | |||||||
 Rice - - | |||||||
 Michigan - -26½ -108Heritage | |||||||
 Mississippi State - -28 -110Bookmaker | |||||||
 LSU - -11 -110MyBookie | |||||||
 Virginia Tech - - | |||||||
 Louisiana Tech - - | |||||||
 Florida - -26 -110BetOnline | |||||||
 Northwestern - - | |||||||
 Louisiana - - | |||||||
 Maryland - - | |||||||
 Brigham Young - - | |||||||
 New Mexico State - - | |||||||
 Arizona - - | |||||||
 San Diego State - - | |||||||
 New Mexico - -12½ -108Heritage | |||||||
 Hawaii - +2½ -110MyBookie | |||||||
 Arizona State - - | |||||||
 Sacramento State - - | |||||||
 California - PK -110BetOnline | |||||||
 Nevada - +3½ -115BetOnline | |||||||
 Washington - -21½ -108Heritage | |||||||
 Notre Dame - -20½ -104Bookmaker | |||||||
 Ole Miss - -4½ -110BetOnline | |||||||
Florida State - +3 -115BetOnline |
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