Iowa Hawkeyes vs Iowa State Cyclones Odds

As we gear up for the much-anticipated Saturday football clash on September 6, 2025, between the Iowa State Cyclones and the Iowa Hawkeyes at Jack Trice Stadium in Ames, IA, excitement is in the air. This NCAAF showdown promises to be electrifying, with both teams eager to make their mark in the 2025-26 season. The Cyclones, playing at home, are slightly favored with a point spread of -3.5 -110, while the Hawkeyes are at +3.5 -110, according to Caesars. This spread indicates a competitive game, with both teams having compelling reasons to win.

For bettors, the odds offer intriguing possibilities. The Cyclones are the favorites with a moneyline of -170, while the Hawkeyes stand at +143, presenting a potential payout for those willing to take a risk on the underdog. The total points market is set at 43, with over and under both priced at -110, suggesting a tight contest.

Catch all the action live on FOX, and for those looking to bet smart, Start your OddsTrader Turbo subscription to stay ahead with real-time insights and updates. For more detailed odds and betting lines, check out our NCAAF odds page. With the Cyclones' home advantage and the Hawkeyes' determination, this game is set to be a thrilling encounter. Ready to place your bets? Make sure to compare the latest lines and find the best odds available.