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FINAL
Sep 6, 2025 12:00 PM EDT
IOWA 13 vs ISU 16
Week 2
ISU
-3 (-113)o43 (-110)
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Iowa Hawkeyes Vs Iowa State Cyclones Picks
Updated:Sep 6, 2025 5:12 AM EDT
The Iowa State Cyclones are set to face off against the Iowa Hawkeyes on September 6, 2025, at Jack Trice Stadium in Ames, IA. This NCAAF Week 2 clash promises an exciting showdown as the Cyclones, coming off a strong performance against the South Dakota Coyotes, aim to maintain their momentum. The game will be broadcasted on Fox, making it accessible for fans and bettors alike. Our picks suggest a slight edge for Iowa State with a predicted score of 24-19. Considering the point spread, Iowa State at -3.5 offers a favorable betting opportunity.
Our prediction model has been quite profitable, especially in the American Total market, boasting a 62.2% hit rate in previous games. The Over 41.5 market presents a promising EV, making it a smart choice for bettors looking to capitalize on this matchup. Historically, our picks have performed well, with a consistent track record of accuracy, which is something bettors can rely on.
For those looking to enhance their betting strategy, start your OddsTrader Turbo subscription today and gain an edge with comprehensive insights. Additionally, explore more of our expert analyses on the NCAAF picks page to stay ahead of the game.
UPCOMING GAME PREDICTION
Spread
Money
Total
ISUSpread
CONSENSUS LINE
-3 (-117)
PROJECTION
IOWA (20) - ISU (25)
COVER PROBABILITY
EXPECTED VALUE
+7.2%
BET RATING
SEASON COVER %
2/2
100%
NCAAF
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Top 25
Top 25
Div. II & III
NCAAFEast-West shrine game
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