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FINAL
Nov 29, 2025 12:00 PM EST
UK 0 vs LOU 41
Week 14
UK
-1 (-110)o45 (-115)
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Kentucky Wildcats vs Louisville Cardinals Betting Trends
Updated:Nov 29, 2025 1:50 AM EST
The upcoming Saturday football game on November 29, 2025, between the Kentucky Wildcats and Louisville Cardinals at L&N Federal Credit Union Stadium in Louisville, KY, is a must-watch in the 2025-26 NCAAF season. This matchup features a clash of strong offenses and defenses, with Louisville holding a slight edge as the favorite with a -2.5 point spread and an over/under set at 46.5 points. Kentucky's offense averages 359.4 total yards per game, with a balanced attack of 211 passing yards and 148 rushing yards, while Louisville's offense is slightly more productive with 384 total yards per game, including 230 passing yards and 154 rushing yards.
Quarterback play is crucial here, with Louisville's starter expected to lead the charge despite a recent loss. Kentucky's defense shows strength against the pass, allowing just around 245 passing yards per game, but Louisville's balanced attack and efficient pass protection could challenge that. On the other side, Louisville's defense allows 314 total yards per game, and Kentucky's offense will look to exploit that with its effective run game and solid pass protection.
The previous matchup on November 30, 2024, saw Louisville dominate Kentucky 41-14 at Kroger Field, a game that Louisville covered the spread comfortably. Kentucky has a mixed ATS record on the road, while Louisville struggles ATS at home, making this an intriguing betting battle. The game will be broadcast on ESPN networks and ACC Network, providing excellent viewing options for fans and bettors alike.
These betting trends, combined with game insights from recent performances, suggest Louisville's home advantage and offensive firepower give them the edge, but Kentucky's defense and balanced attack could keep it close. The total points line at 46.5 indicates a moderately high-scoring affair, appealing to those considering over bets.
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ATS Records
All
5-7 (189th)Against the Spread4-9 (246th)
5-7 (172nd)Straight Up9-4 (57th)
-1.9Straight Up Units+1.5
8-4Over / Under6-7
TEAM MATCHUP
OFF
DEF
OFF
DEF
23Points29.9
341.1Total Yards384.5
5.2Yards Per Play6
201.9Passing Yards220.6
19.1 - 30.7 (62.2%)Completions-Attempts20.6 - 32.2 (64.1%)
6.6Yards Per Passing Play6.9
15.5Sacks-Yards Lost13.9
139.2Rushing Yards163.9
36Attempts32.4
3.9Yards Per Rush5.1
19.81st Downs19.8
9.8Passing9.6
8.2Rushing8.5
1.8Penalties1.7
5.3 / 13.2 (40.5%)3rd Down4.5 / 12.8 (35.3%)
0.9 / 1.8 (52.4%)4th Down0.7 / 1.1 (64.3%)
2.3 / 3 (77.8%)Red Zone2.9 / 3.2 (90.5%)
5 (41)Penalties (Yards)6.9 (63.2)
1.2Interceptions0.7
0.8Fumbles Lost0.6
69.1Total Plays66.5
4.9Kickoffs6.2
1.3Returns1.3
23.1Yards28.3
18.5Yards Per Return21.6
4.3Punts4.4
1.1Returns2.3
4.4Yards38.5
4.1Yards Per Return16.7
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