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FINAL
Nov 22, 2025 12:00 PM EST
LOU 6 vs SMU 38
Week 13
SMU
-3½ (-110)o50 (-105)
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Louisville Cardinals vs SMU Mustangs Betting Trends
Updated:Nov 22, 2025 2:25 AM EST
Get ready for Saturday football on November 22, 2025, as the Louisville Cardinals face off against the SMU Mustangs at Gerald J. Ford Stadium in Dallas, TX. This NCAAF matchup offers a compelling battle of strengths and weaknesses that bettors should closely watch.
The Louisville Cardinals, with a 7-3 straight-up record and a solid 3-0 away ATS record, bring a strong passing offense averaging 243.3 yards per game against SMU's defense, which allows 298.6 passing yards. The Mustangs counter with a balanced offense averaging 284.5 passing yards and 122.1 rushing yards, while Louisville's defense allows 188 passing yards and 109.9 rushing yards. This contrast sets up an intriguing pass offense vs pass defense and run offense vs run defense dynamic.
Quarterback depth and health are crucial. Louisville's starting QB is expected to play, providing stability, while SMU's QB leads an offense that scores 32.2 points per game compared to Louisville's 31.5. SMU's pass rush, with 3.3 sacks per game, challenges Louisville's pass protection, which allows 1.9 sacks, hinting at a tough battle in the trenches.
The betting odds favor SMU by 4 points with a total of 50 points, signaling a close game with moderate scoring. Considering Louisville's strong away ATS record and recent performances, including a 34-27 win over Louisville on October 5, 2024, bettors can find value in this matchup. In their last meeting on October 5, 2024, Louisville Cardinals fell to SMU Mustangs 27-34, a game that went OVER 55.5 points, which you can explore further in the detailed last matchup analysis.
For bettors seeking an edge, these betting trends and game insights provide a solid foundation to make informed decisions. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.
ATS Records
All
4-9 (246th)Against the Spread6-7 (155th)
9-4 (57th)Straight Up9-4 (62nd)
+1.5Straight Up Units+1.8
6-7Over / Under4-9
TEAM MATCHUP
OFF
DEF
OFF
DEF
29.9Points32.2
384.5Total Yards417
6Yards Per Play6.2
220.6Passing Yards283.1
20.6 - 32.2 (64.1%)Completions-Attempts23.5 - 35.4 (66.3%)
6.9Yards Per Passing Play8
13.9Sacks-Yards Lost14.2
163.9Rushing Yards133.9
32.4Attempts30.8
5.1Yards Per Rush4.3
19.81st Downs20.7
9.6Passing11.3
8.5Rushing7.4
1.7Penalties2
4.5 / 12.8 (35.3%)3rd Down5.3 / 13 (40.8%)
0.7 / 1.1 (64.3%)4th Down0.6 / 0.9 (66.7%)
2.9 / 3.2 (90.5%)Red Zone3.1 / 3.4 (90.9%)
6.9 (63.2)Penalties (Yards)7 (70.8)
0.7Interceptions1
0.6Fumbles Lost0.5
66.5Total Plays67.7
6.2Kickoffs6.2
1.3Returns1.2
28.3Yards24.2
21.6Yards Per Return19.6
4.4Punts4.2
2.3Returns1.3
38.5Yards12.9
16.7Yards Per Return9.9
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NCAAFWeek 1
NCAAF Sat 08/29
 TCU - -6½ -110Bovada | |||||||
 Valparaiso - - | |||||||
 USC - -35½ -108Heritage | |||||||
 Virginia - -3 -110MyBookie | |||||||
 North Dakota State - -8½ -105BetOnline | |||||||
 Eastern Michigan - -7½ -110Bovada | |||||||
 Florida State - -30½ -108Heritage | |||||||
 Stanford - -3½ -108Heritage | |||||||
 UNLV - -3 -115Bookmaker | |||||||
 Rutgers - -30½ -108Heritage | |||||||
 Wake Forest - -22½ -108Heritage | |||||||
 Kennesaw State - - | |||||||
 Buffalo - - | |||||||
 Delaware - - | |||||||
 UCF - - | |||||||
 Georgia Tech - -7 -110BetOnline | |||||||
 Minnesota - - | |||||||
 Missouri - - | |||||||
 Illinois - -27½ -108Heritage | |||||||
 Utah - - | |||||||
Eastern Michigan - -3½ -108Heritage | |||||||
 Georgia State - - | |||||||
 Purdue - - | |||||||
 Michigan State - -10½ -105BetOnline | |||||||
 Kansas - - | |||||||
USC - -22½ -110BetOnline | |||||||
Stanford - +23 -105BetOnline | |||||||
 West Virginia - -17½ -105BetOnline | |||||||
 James Madison - -6 -110BetOnline | |||||||
 Indiana - -39½ -108Heritage | |||||||
 Alabama - -26½ -108Heritage | |||||||
 Nebraska - -23½ -105BetOnline | |||||||
 Houston - -18½ -108Heritage | |||||||
 Connecticut - - | |||||||
 Syracuse - - | |||||||
 Bowling Green - - | |||||||
 Army - - | |||||||
 Pittsburgh - -15½ -110Bovada | |||||||
 Ohio State - -49½ -110BetOnline | |||||||
 South Carolina - -34½ -108Heritage | |||||||
 Oklahoma - -40½ -105BetOnline | |||||||
 Iowa State - - | |||||||
 Kentucky - - | |||||||
 Air Force - - | |||||||
 Temple - - | |||||||
 Georgia - - | |||||||
 Cincinnati - -7½ -108Heritage | |||||||
 Penn State - -22½ -110BetOnline | |||||||
 Duke - -8 -110Bookmaker | |||||||
 Texas - -30½ -110BetOnline | |||||||
 Oregon - -24½ -108Heritage | |||||||
 Auburn - -7 -105Bookmaker | |||||||
 Tennessee - - | |||||||
 Appalachian State - - | |||||||
 Charlotte - - | |||||||
 UTSA - - | |||||||
North Dakota State - - | |||||||
 Navy - - | |||||||
 Tulsa - +12½ -108Heritage | |||||||
 Iowa - -30 -110Bookmaker | |||||||
 Arkansas - - | |||||||
 Southern Miss - - | |||||||
 Colorado State - -3½ -108Heritage | |||||||
 Old Dominion - - | |||||||
 South Florida - -12 -108Heritage | |||||||
 Texas A&M - -38½ -110BetOnline | |||||||
 Troy - -17 -112Bookmaker | |||||||
 Memphis - -10½ -108Heritage | |||||||
 South Alabama - - | |||||||
 Middle Tennessee - - | |||||||
 Kansas State - - | |||||||
 Utah State - - | |||||||
 Jacksonville State - - | |||||||
 Vanderbilt - - | |||||||
 Georgia Southern - - | |||||||
 Texas Tech - - | |||||||
 Rice - - | |||||||
 Michigan - -26½ -108Heritage | |||||||
 Mississippi State - -28 -110Bookmaker | |||||||
 LSU - -11 -110MyBookie | |||||||
 Virginia Tech - - | |||||||
 Louisiana Tech - - | |||||||
 Florida - -26 -110BetOnline | |||||||
 Northwestern - - | |||||||
 Louisiana - - | |||||||
 Maryland - - | |||||||
 Brigham Young - - | |||||||
 New Mexico State - - | |||||||
 Arizona - - | |||||||
 San Diego State - - | |||||||
 New Mexico - -12 -108Heritage | |||||||
 Hawaii - +2½ -110MyBookie | |||||||
 Arizona State - - | |||||||
 Sacramento State - - | |||||||
 California - PK -110BetOnline | |||||||
 Nevada - +3½ -115BetOnline | |||||||
 Washington - -21½ -108Heritage | |||||||
 Notre Dame - -20½ -108Heritage | |||||||
 Ole Miss - -4½ -110BetOnline | |||||||
Florida State - +3 -115BetOnline |
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