FINAL

Nov 22, 2025 12:00 PM EST

LOU 6 vs SMU 38

Week 13

FINAL

-3½ (-110)o50 (-105)

ESPN2, 209

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Louisville Cardinals vs SMU Mustangs Odds

Updated:Nov 22, 2025 2:01 AM EST

The upcoming matchup on November 22, 2025, features the Louisville Cardinals taking on the SMU Mustangs at Gerald J. Ford Stadium in Dallas, TX. This Saturday football game in the NCAAF promises excitement as both teams vie for a crucial win in Week 13 of the regular season. Fans can catch the action live on ESPN2, making it a prime opportunity to follow the latest odds and betting lines.

Currently, the SMU Mustangs are favored with a point spread of -4 -111, while the Louisville Cardinals hold +4 -110 on the spread. The over under is set at 50 -110, indicating a balanced expectation for scoring. Opening odds saw a similar spread, but the slight movement in the point spread odds suggests bettor confidence leaning towards SMU. Understanding these odds and betting lines can help bettors make informed decisions to maximize their chances of winning.

For those interested in deeper analysis, the NCAAF odds page offers comprehensive insights into all games this season. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.

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NCAAF

ODDS PICKS PLAYER PROPS FUTURES PLAYER FUTURES WEATHER RANKINGS STANDINGS

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NCAAF Sat 08/29

Personalize your notifications and get updates on the teams, players or events you care about most. SAT 08/2912:00 PM North Carolina - +7 -115BetOnline
TCU - -6½ -110Bovada
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 08/292:00 PM LT Lawrence Tech - -
Valparaiso - -
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 08/293:00 PM San Jose State - +35½ -108Heritage
USC - -35½ -108Heritage
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 08/293:30 PM North Carolina State - +6½ -115BetOnline
Virginia - -3 -110MyBookie
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 08/295:30 PM Jacksonville State - +8½ -108Heritage
North Dakota State - -8½ -105BetOnline
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 08/296:30 PM Sacramento State - +8 -108Heritage
Eastern Michigan - -7½ -110Bovada
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 08/297:00 PM New Mexico State - +31 -110BetOnline
Florida State - -30½ -108Heritage
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 08/297:00 PM Hawaii - +4 -110Bookmaker
Stanford - -3½ -108Heritage
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 08/2910:00 PM Memphis - +3½ -105BetOnline
UNLV - -3 -115Bookmaker
Personalize your notifications and get updates on the teams, players or events you care about most. THU 09/036:00 PM Massachusetts - +30½ -108Heritage
Rutgers - -30½ -108Heritage
Personalize your notifications and get updates on the teams, players or events you care about most. THU 09/037:00 PM Akron - +22½ -108Heritage
Wake Forest - -22½ -108Heritage
Personalize your notifications and get updates on the teams, players or events you care about most. THU 09/037:00 PM West Georgia - -
Kennesaw State - -
Personalize your notifications and get updates on the teams, players or events you care about most. THU 09/037:00 PM Albany - -
Buffalo - -
Personalize your notifications and get updates on the teams, players or events you care about most. THU 09/037:00 PM Merrimack College - -
Delaware - -
Personalize your notifications and get updates on the teams, players or events you care about most. THU 09/037:00 PM Bethune-Cookman - -
UCF - -
Personalize your notifications and get updates on the teams, players or events you care about most. THU 09/038:00 PM Colorado - +7½ -110Bovada
Georgia Tech - -7 -110BetOnline
Personalize your notifications and get updates on the teams, players or events you care about most. THU 09/038:00 PM Eastern Illinois - -
Minnesota - -
Personalize your notifications and get updates on the teams, players or events you care about most. THU 09/038:00 PM Arkansas-Pine Bluff - -
Missouri - -
Personalize your notifications and get updates on the teams, players or events you care about most. THU 09/039:00 PM UAB - +27½ -108Heritage
Illinois - -27½ -108Heritage
Personalize your notifications and get updates on the teams, players or events you care about most. THU 09/039:00 PM Idaho - -
Utah - -
Personalize your notifications and get updates on the teams, players or events you care about most. FRI 09/046:30 PM San Jose State - +4½ -110BetOnline
Eastern Michigan - -3½ -108Heritage
Personalize your notifications and get updates on the teams, players or events you care about most. FRI 09/047:00 PM North Carolina A&T - -
Georgia State - -
Personalize your notifications and get updates on the teams, players or events you care about most. FRI 09/047:00 PM Indiana State - -
Purdue - -
Personalize your notifications and get updates on the teams, players or events you care about most. FRI 09/048:00 PM Toledo - +10½ -108Heritage
Michigan State - -10½ -105BetOnline
Personalize your notifications and get updates on the teams, players or events you care about most. FRI 09/048:00 PM LIU - -
Kansas - -
Personalize your notifications and get updates on the teams, players or events you care about most. FRI 09/049:00 PM Fresno State - +23½ -108Heritage
USC - -22½ -110BetOnline
Personalize your notifications and get updates on the teams, players or events you care about most. FRI 09/049:00 PM Miami (FL) - -22 -108Heritage
Stanford - +23 -105BetOnline
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/0512:00 PM Coastal Carolina - +17½ -108Heritage
West Virginia - -17½ -105BetOnline
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/0512:00 PM Liberty - +6½ -108Heritage
James Madison - -6 -110BetOnline
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/0512:00 PM North Texas - +40½ -110BetOnline
Indiana - -39½ -108Heritage
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/0512:00 PM East Carolina - +26½ -105BetOnline
Alabama - -26½ -108Heritage
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/0512:00 PM Ohio - +23½ -108Heritage
Nebraska - -23½ -105BetOnline
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/0512:00 PM Oregon State - +18½ -108Heritage
Houston - -18½ -108Heritage
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/0512:00 PM Lafayette - -
Connecticut - -
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/0512:00 PM New Hampshire - -
Syracuse - -
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/0512:00 PM Tarleton State - -
Bowling Green - -
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/0512:00 PM Bryant University - -
Army - -
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/0512:30 PM Miami (OH) - +16½ -110BetOnline
Pittsburgh - -15½ -110Bovada
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/0512:30 PM Ball State - +50½ -110Bovada
Ohio State - -49½ -110BetOnline
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/0512:45 PM Kent State - +34½ -105BetOnline
South Carolina - -34½ -108Heritage
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/051:00 PM UTEP - +40½ -108Heritage
Oklahoma - -40½ -105BetOnline
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/051:00 PM Southeast Missouri State - -
Iowa State - -
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/051:00 PM Youngstown State - -
Kentucky - -
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/051:00 PM Duquesne - -
Air Force - -
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/052:00 PM Rhode Island - -
Temple - -
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/053:00 PM Tennessee State - -
Georgia - -
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/053:30 PM Boston College - +7½ -108Heritage
Cincinnati - -7½ -108Heritage
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/053:30 PM Marshall - +23½ -108Heritage
Penn State - -22½ -110BetOnline
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/053:30 PM Tulane - +10 -110BetOnline
Duke - -8 -110Bookmaker
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/053:30 PM Texas State - +31 -108Heritage
Texas - -30½ -110BetOnline
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/053:30 PM Boise State - +24½ -105Bovada
Oregon - -24½ -108Heritage
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/053:30 PM Baylor - +7 -104Heritage
Auburn - -7 -105Bookmaker
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/053:30 PM Furman - -
Tennessee - -
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/053:30 PM Maine - -
Appalachian State - -
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/053:30 PM Citadel - -
Charlotte - -
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/053:30 PM UT Rio Grande Valley - -
UTSA - -
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/053:30 PM Fordham - -
North Dakota State - -
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/053:30 PM Towson - -
Navy - -
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/053:45 PM Oklahoma State - -12½ -108Heritage
Tulsa - +12½ -108Heritage
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/054:15 PM Northern Illinois - +30½ -105BetOnline
Iowa - -30 -110Bookmaker
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/054:15 PM North Alabama - -
Arkansas - -
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/055:00 PM Alcorn State - -
Southern Miss - -
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/056:00 PM Wyoming - +4 -110BetOnline
Colorado State - -3½ -108Heritage
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/056:00 PM Norfolk State - -
Old Dominion - -
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/057:00 PM Florida International - +12½ -110BetOnline
South Florida - -12 -108Heritage
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/057:00 PM Missouri State - +39 -108Heritage
Texas A&M - -38½ -110BetOnline
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/057:00 PM Sam Houston State - +18 -110BetOnline
Troy - -17 -112Bookmaker
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/057:00 PM Arkansas State - +10½ -108Heritage
Memphis - -10½ -108Heritage
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/057:00 PM Southeastern Louisiana - -
South Alabama - -
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/057:00 PM Murray State - -
Middle Tennessee - -
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/057:00 PM Nicholls State - -
Kansas State - -
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/057:00 PM Idaho State - -
Utah State - -
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/057:00 PM Eastern Kentucky - -
Jacksonville State - -
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/057:00 PM Austin Peay - -
Vanderbilt - -
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/057:00 PM Charleston Southern - -
Georgia Southern - -
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/057:00 PM Abilene Christian - -
Texas Tech - -
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/057:00 PM Houston Christian - -
Rice - -
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/057:30 PM Western Michigan - +27 -110Bookmaker
Michigan - -26½ -108Heritage
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/057:30 PM Louisiana-Monroe - +28½ -108Heritage
Mississippi State - -28 -110Bookmaker
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/057:30 PM Clemson - +11½ -108Heritage
LSU - -11 -110MyBookie
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/057:30 PM Virginia Military Institute - -
Virginia Tech - -
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/057:30 PM Northwestern State - -
Louisiana Tech - -
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/057:45 PM Florida Atlantic - +26½ -108Heritage
Florida - -26 -110BetOnline
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/058:00 PM South Dakota State - -
Northwestern - -
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/058:00 PM Lamar - -
Louisiana - -
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/058:00 PM Hampton - -
Maryland - -
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/058:00 PM Utah Tech - -
Brigham Young - -
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/059:00 PM Mercyhurst University - -
New Mexico State - -
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/059:30 PM Northern Arizona - -
Arizona - -
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/059:30 PM Portland State - -
San Diego State - -
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/0510:00 PM Central Michigan - +12½ -110BetOnline
New Mexico - -12 -108Heritage
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/0510:00 PM UNLV - -1 -105BetOnline
Hawaii - +2½ -110MyBookie
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/0510:00 PM Morgan State - -
Arizona State - -
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/0510:00 PM Mississippi Valley State - -
Sacramento State - -
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/0510:30 PM UCLA - +1½ -110Bovada
California - PK -110BetOnline
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 09/0510:30 PM Western Kentucky - -3 -108Heritage
Nevada - +3½ -115BetOnline
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 09/064:00 PM Washington State - +21½ -108Heritage
Washington - -21½ -108Heritage
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 09/067:30 PM Wisconsin - +20½ -108Heritage
Notre Dame - -20½ -108Heritage
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 09/067:30 PM Louisville - +6½ -110Bovada
Ole Miss - -4½ -110BetOnline
Personalize your notifications and get updates on the teams, players or events you care about most. MON 09/077:30 PM SMU - -2½ -113Bookmaker
Florida State - +3 -115BetOnline

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