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FINAL
Sep 27, 2025 3:30 PM EDT
LSU 19 vs MISS 24
Week 5
7-6
#13 LSU
19
FINAL
24
13-2
#4 Ole Miss
MISS
-2½ (-120)o57 (-123)
tvABC, ESPN Networks
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LSU Tigers vs Ole Miss Rebels Betting Trends

Updated:Sep 27, 2025 5:15 AM EDT

Before the much-anticipated showdown on September 27, 2025, between the LSU Tigers and the Ole Miss Rebels at Vaught-Hemingway Stadium in Oxford, MS, fans and bettors alike are gearing up for a thrilling encounter. LSU's offense, led by their dynamic quarterback, is expected to challenge Ole Miss's defense, which has been solid against the run but vulnerable to the pass. LSU's recent performances, including a decisive 56-10 victory over Southeastern Louisiana, highlight their offensive prowess, particularly in the passing game. Meanwhile, Ole Miss is riding high on a 45-10 win against Tulane, showcasing their balanced attack.

With both teams undefeated, the stakes are high. The Point Spread is set at Ole Miss -1.5, with a total points line of 57.5. Given LSU's strong passing offense and Ole Miss's formidable running game, expect a high-scoring affair that could easily surpass the total points line. This game is a must-watch on ABC and ESPN networks, providing ample betting opportunities with intriguing odds.

For those looking to dive into detailed betting trends, Start your OddsTrader Turbo subscription to gain an edge. With LSU's quarterback advantage and Ole Miss's home-field prowess, this matchup promises to be a Saturday football classic. Check out our NCAAF standings page for the latest records.

Who is favored to win between LSU Tigers and Ole Miss Rebels?

ATS Records

LSU

Ole Miss

All
  • All
  • 1st half
  • 2nd half
  • 1st quarter
  • 2nd quarter
  • 3rd quarter
  • 4th quarter
4-9 (248th)Against the Spread9-6 (57th)
7-6 (125th)Straight Up13-2 (8th)
-2.9Straight Up Units+4.1
4-9Over / Under8-7

TEAM MATCHUP

LSU

Ole Miss

OFF
DEF
OFF
DEF
22.9Points36.9
333.5Total Yards489.7
5.2Yards Per Play6.8
229.5Passing Yards313.3
22.4 - 34.1 (65.7%)Completions-Attempts22.7 - 34.9 (65%)
6.7Yards Per Passing Play9
17.2Sacks-Yards Lost6.5
104Rushing Yards176.3
29.1Attempts38.4
3.6Yards Per Rush4.6
18.71st Downs25.5
10.9Passing13.3
5.5Rushing9.9
2.2Penalties2.3
4.9 / 13.3 (37%)3rd Down5.6 / 13 (43.1%)
0.6 / 1 (61.5%)4th Down1.4 / 2.1 (67.7%)
2.8 / 3.4 (81.8%)Red Zone4.4 / 5.1 (85.7%)
7 (59.3)Penalties (Yards)5.5 (52.4)
0.5Interceptions0.5
0.5Fumbles Lost0.3
65.4Total Plays74.5
5.2Kickoffs7.3
1.8Returns0.6
43.2Yards12.5
24.4Yards Per Return20.9
4.8Punts2.7
1.3Returns1.1
12.2Yards7.9
9.3Yards Per Return7.4

Recent Results

LSU

Ole Miss

Game
Score
ATS
O/U
vs Southeastern Louisiana
Sep 20, 2025
W
56-10
L
-48½
O
60½
vs Florida
Sep 13, 2025
W
20-10
W
-4½
U
47½
vs Louisiana Tech
Sep 6, 2025
W
23-7
L
-36½
U
49½
at Clemson
Aug 30, 2025
W
17-10
W
+5½
U
55½
vs Baylor
Dec 31, 2024
W
44-31
W
+3½
O
62½
vs Oklahoma
Nov 30, 2024
W
37-17
W
-6
O
48
vs Vanderbilt
Nov 23, 2024
W
24-17
L
-10
U
52½
at Florida
Nov 16, 2024
L
16-27
L
-3½
U
57
vs Alabama
Nov 9, 2024
L
13-42
L
+3
U
59½
at Texas A&M
Oct 26, 2024
L
23-38
L
+2
O
54½
Game
Score
ATS
O/U
vs Tulane
Sep 20, 2025
W
45-10
W
-11
U
61½
vs Arkansas
Sep 13, 2025
W
41-35
W
-3½
O
60
at Kentucky
Sep 6, 2025
W
30-23
L
-8½
O
51
vs Georgia State
Aug 30, 2025
W
63-7
W
-33½
O
60½
vs Duke
Jan 2, 2025
W
52-20
W
-18
O
51
vs Mississippi State
Nov 29, 2024
W
26-14
L
-25
U
63½
at Florida
Nov 23, 2024
L
17-24
L
-13½
U
57½
vs Georgia
Nov 9, 2024
W
28-10
W
+2
U
54½
at Arkansas
Nov 2, 2024
W
63-31
W
-7½
O
54
vs Oklahoma
Oct 26, 2024
W
26-14
L
-19
U
50
View Full Season Game Log

HEAD TO HEAD

LSU

LSU

Ole Miss

MISS
Matchup
SU
ATS
O/U
Ole Miss @ LSUOct 12, 2024
26-29
LSU
+4
LSU
64½
U
LSU @ Ole MissSep 30, 2023
49-55
MIS
+3
MIS
66½
O
Ole Miss @ LSUOct 22, 2022
20-45
LSU
-1
LSU
64
O
LSU @ Ole MissOct 23, 2021
17-31
MIS
-9½
MIS
77
U
Ole Miss @ LSUDec 19, 2020
48-53
LSU
+1
LSU
74½
O

LSU

UPCOMING SCHEDULE

Ole Miss

Matchup
Date
Time
vs South Carolina
tvSEC Network, ESPN Networks, 611
Oct 11, 2025
19:45 EDT
at Vanderbilt
tvABC, ESPN Networks
Oct 18, 2025
12:00 EDT
vs Texas A&M
tvABC, ESPN Networks
Oct 25, 2025
19:30 EDT
at Alabama
tvABC, ESPN Networks
Nov 8, 2025
19:30 EST
vs Arkansas
tvSEC Network, ESPN Networks, 611
Nov 15, 2025
12:45 EST
Matchup
Date
Time
vs Washington State
tvSEC Network, 611
Oct 11, 2025
12:45 EDT
at Georgia
tvABC, ESPN Networks
Oct 18, 2025
15:30 EDT
at Oklahoma
tvABC, ESPN Networks
Oct 25, 2025
12:00 EDT
vs South Carolina
tvESPN, 206, ESPN Networks
Nov 1, 2025
19:00 EDT
vs Citadel
tvSEC Network+
Nov 8, 2025
13:00 EST
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