Nebraska Cornhuskers vs Penn State Nittany Lions Betting Trends

The upcoming Saturday football clash on November 22, 2025, features the Nebraska Cornhuskers visiting the Penn State Nittany Lions at West Shore Home Field at Beaver Stadium in University Park, PA. This NCAAF regular season Week 13 game promises exciting betting trends and game insights for fans and bettors alike. The Nittany Lions will be favored with a -7.5 point spread and a total points line set at 44.5, indicating a moderately paced game with a defensive edge.

Nebraska's offense averages 248.2 passing yards and 137.4 rushing yards per game, while Penn State’s defense holds opponents to 167.7 passing yards and 148.4 rushing yards on average. This suggests a competitive matchup between Nebraska's passing offense and Penn State's defensive capabilities. Penn State’s offense, led by their starting quarterback, averages 178.9 passing yards and 159.9 rushing yards, facing Nebraska's defense that allows 134.6 passing yards and 161.1 rushing yards per game, indicating a slight edge for Penn State’s run game against Nebraska's run defense.

Both teams have shown mixed results recently. Nebraska holds a 7-3 straight-up record and a 4-5-1 against the spread, while Penn State is 4-6 straight up and 3-7 ATS. Nebraska's recent win against UCLA and Penn State's win over Michigan State highlight their potential. The game will be broadcast on NBC, making it accessible for fans to catch all the action live.

With the point spread favoring Penn State, bettors should consider the balance of pass protection against pass rush, and how each team's offensive line will perform under pressure. The total points line at 44.5 suggests a game leaning towards under, but with both teams capable of scoring, the over remains a viable option. For detailed betting trends and to make smarter wagers, check out our OddsTrader Turbo page and place your bets with a U.S. regulated sportsbook.

In their previous encounter on November 14, 2020, the Nebraska Cornhuskers edged out Penn State 30-23 in a tightly contested game that went under the 57.5 points total. You can find more about that matchup on our page.