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The upcoming NFL showdown on December 21, 2025, features the Los Angeles Chargers visiting the Dallas Cowboys at the iconic AT&T Stadium in Arlington, TX. This highly anticipated Week 16 regular season game promises intense Sunday football action, broadcast on FOX. Fans and bettors alike will be keenly watching as the Cowboys, led by starting quarterback Dak Prescott, face off against the Chargers' dynamic offense spearheaded by Justin Herbert, who is expected to play despite being listed as questionable but showing full participation in practice.
Analyzing the betting trends, the Cowboys hold a slight edge as favorites with a -2.5 point spread and total points set at 49.5, suggesting a moderately high-scoring game. Dallas boasts a strong home record of 4-2 and an ATS record of 4-3 at home, while the Chargers have a solid 10-4 overall record but struggle away with a 2-4 ATS record. The Cowboys' pass offense averages 276.1 yards per game, facing a Chargers pass defense allowing just 174.4 yards, indicating a tough challenge for Dallas's aerial attack. Conversely, the Chargers' passing offense averages 214.5 yards against a Cowboys defense allowing 254.8 yards, hinting at potential opportunities through the air.
In the rushing departments, Dallas averages 120.8 yards on the ground versus the Chargers' run defense allowing 104.7 yards, suggesting a slight advantage for the Cowboys in the run game. The Chargers' rushing offense averages 123.4 yards against a Cowboys defense giving up 120.1 yards, indicating a balanced ground battle is likely. Pass protection and pass rush also play key roles; Dallas faces a Chargers pass rush with 2.9 sacks per game, while the Chargers confront a Cowboys pass rush averaging 2.1 sacks, potentially influencing quarterback performance.
Recent form shows Dallas losing close games but maintaining competitiveness, while the Chargers have won several recent matches, including a narrow win over the Kansas City Chiefs. Injuries to key players like Dallas's Trevon Diggs (questionable) and Chargers' Keenan Allen (did not practice) could impact defensive and offensive dynamics. The best bet leans toward Dallas covering the spread at home, supported by their home ATS success and balanced offensive stats. For further strategic betting insights and to place your wager, check out our detailed OddsTrader Turbo subscription or bet with a trusted U.S. sportsbook.
In their last matchup on August 24, 2024, the Chargers edged out the Cowboys 26-19 at the same venue, a game worth reviewing for trends and adjustments heading into this December clash.
Seattle 11-355% -1½ -108FanDuel | |||||||
![]() Washington 4-1085% +6½ -110Caesars | |||||||
![]() Chicago 10-446% +1½ -120FanDuel | |||||||
Cleveland 3-1143% +10½ -114Caesars | |||||||
New Orleans 4-1088% -4½ -110Bet365 | |||||||
![]() N.Y. Giants 2-1249% +3 -113Caesars | |||||||
Carolina 7-787% +3 -110Bet365 | |||||||
![]() Tennessee 2-1286% +3 -105Bet365 | |||||||
Dallas 6-7-142% -2 -110Bet365 | |||||||
Miami 6-866% +4½ -110BetRivers | |||||||
Arizona 3-1127% +3 -113Caesars | |||||||
Denver 12-257% -3 -110Bet365 | |||||||
Detroit 8-66% -6½ -120FanDuel | |||||||
![]() Houston 9-542% -14 -108BetRivers | |||||||
![]() Baltimore 7-769% -2½ -121SugarHouse | |||||||
![]() Indianapolis 8-684% +6½ -110BetMGM |
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