Buffalo Bills vs New England Patriots Betting Trends

The upcoming showdown between the Buffalo Bills and New England Patriots on December 14, 2025, at Gillette Stadium in Foxborough, MA, is set to be a thrilling display of NFL talent and strategy. This Sunday football clash is highly anticipated, with the Bills coming in as favorites with a point spread of -1 and an over/under of 49.5 points, broadcasted on CBS.

Josh Allen leads the Bills' offense, known for his strong passing game averaging 225.9 yards per game, complemented by a solid run attack with 157.8 rushing yards total. The Bills' offensive line faces a tough New England pass rush, which has recorded 13.7 sacks on average, challenging Allen's pass protection. Meanwhile, New England's defense is stout, allowing only 296.4 yards per game and holding opponents to 18.5 first downs on average.

The Patriots, starting quarterback Joshua Dobbs, offer a balanced attack with 249.7 passing yards and 112.9 rushing yards per game. They face a Buffalo defense that excels in limiting passing yards to 171.8 and rushing yards to 135.2. This matchup features contrasting styles and strengths, making betting insights crucial for smart wager decisions.

The Patriots hold an impressive 11-2 record straight up and a strong 9-4 against the spread, while the Bills are 9-4 straight up but 6-7 against the spread. Recent form shows New England winning comfortably against the Giants 33-15, and Buffalo edging out the Bengals 39-34. Injuries to key players like Joey Bosa and Mitchell Trubisky remain questionable but expected to play, potentially impacting game dynamics.

Historical context adds intrigue, with the Patriots narrowly winning their last encounter 23-20 on October 5, 2025, at Highmark Stadium, a game that stayed under the total points line of 49. This history can inform current betting trends and strategies.

For bettors looking to capitalize on this high-stakes NFL game, understanding these betting trends and game insights is essential. The detailed stats on passing versus pass defense, run offense versus run defense, and protection versus rush dynamics provide a competitive edge. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.

The best odds available today for Buffalo Bills is -1 -110 at Caesars and for New England Patriots +1 -109 at Caesars.

In their last matchup on October 5th, 2025, Patriots won 23-20, the Patriots defeated the Bills in a close game that was under the total points line.