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Dec 21, 2025 4:05 PM EST
Week 16
ATL
-2½ (-115)o47½ (-110)
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Atlanta Falcons vs Arizona Cardinals Betting Trends
Updated:Dec 16, 2025 1:33 AM EST
The upcoming NFL matchup on December 21, 2025, features the Atlanta Falcons vs Arizona Cardinals at State Farm Stadium in Glendale, AZ. This Sunday football game is set to be an intense battle with both teams looking to improve their records as the regular season nears its end in Week 16. The Falcons, led by starting quarterback Michael Penix Jr., face the Cardinals, who will start Kyler Murray under center. Despite some questionable injuries, both quarterbacks are expected to play, promising an exciting duel.
Arizona's passing offense averages 238.4 yards per game against a Falcons defense allowing 195.6 yards through the air, suggesting a potential edge for the Cardinals in the aerial game. However, Atlanta's run offense at 27.3 yards per game will test Arizona's solid run defense that allows just 124.5 yards on the ground. Both teams have shown vulnerabilities in pass protection and pass rush, which could lead to critical moments in the game.
Betting trends indicate the Falcons are favored by 2.5 points with a total points line set at 47.5. Recent game stats show Arizona struggling with a 2-8 record, while Atlanta holds a slightly better 4-6 record. The Cardinals have been challenged on both sides of the ball in recent weeks, while the Falcons have been inconsistent but capable of high scoring, making the over 47.5 points an appealing option. The game will be broadcast on FOX, offering fans and bettors comprehensive game insights.
Key players to watch include Kyler Murray and Michael Penix Jr., whose performances could sway the betting stats significantly. The Falcons' ability to cover the spread at home has been strong historically, which can be reviewed on our NFL standings page. This matchup is a must-watch for bettors looking to capitalize on detailed betting trends and sports insights. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge. In their last matchup on November 12, 2023, a close 25-23 game, the Cardinals narrowly defeated the Falcons, adding an exciting storyline to this upcoming game.
All
7-7 (19th)Against the Spread6-8 (24th)
5-9 (23rd)Straight Up3-11 (27th)
-2.0Straight Up Units-8.9
7-7Over / Under9-5
OFF
DEF
OFF
DEF
20.1Points21.6
11.1First Half11.1
9Second Half10.5
4.6First Quarter4.6
6.5Second Quarter6.5
2.9Third Quarter4.9
6.1Fourth Quarter5.6
340.4Total Yards333.4
5.7Yards Per Play5.5
217.7Passing Yards238.4
20 - 32.7 (61.1%)Completions-Attempts26.2 - 39.2 (66.8%)
6.4Yards Per Passing Play5.6
1.5 (11)Sacks (Yards)3.4 (24)
122.7Rushing Yards95
27.3Attempts22.5
4.5Yards Per Rush4.2
19.81st Downs20.5
11Passing13.2
6.9Rushing5.6
1.9Penalties1.7
3.8 / 11.9 (31.9%)3rd Down5.6 / 13.4 (42.2%)
0.8 / 1.6 (50%)4th Down0.6 / 1.6 (36.4%)
1.9 / 3 (61.9%)Red Zone2.2 / 3.9 (57.4%)
6.6 (51.1)Penalties (Yards)7 (52.3)
1.4Turnovers1.3
0.8Interceptions0.6
0.6Fumbles Lost0.6
61.5Total Plays65.1
4.7Kickoffs4.9
4.3Returns4.7
97.5Return Yards118.6
22.8Yards Per Return25.2
3.9Punts3.6
1.4Returns1.1
9.6Return Yards13.2
6.7Yards Per Return11.6
PRIORITYDrake London
Out
5 Wide Receiver
PRIORITYMarvin Harrison Jr.
Out
18 Wide Receiver
HEAD TO HEAD
ESPN, 206
NFL
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NFLWeek 16
 Seattle 11-363% +1½ -120FanDuel | |||||||
 Washington 4-1076% +6½ -110Caesars | |||||||
 Chicago 10-429% +2 -118BetMGM | |||||||
 Cleveland 3-1195% +10½ -122FanDuel | |||||||
 New Orleans 4-10100% -4 -110Bet365 | |||||||
 N.Y. Giants 2-1271% +3 -110Caesars | |||||||
 Carolina 7-758% +3 -110FanDuel | |||||||
 Tennessee 2-1267% +3½ -108Caesars | |||||||
 Dallas 6-7-182% -1½ -115BetMGM | |||||||
 Miami 6-8100% +1½ -120Bet365 | |||||||
 Arizona 3-1143% +2½ -105Bet365 | |||||||
 Denver 12-247% -3 -108BetRivers | |||||||
 Detroit 8-611% -6½ -114FanDuel | |||||||
 Houston 9-511% -14½ -104FanDuel | |||||||
 Baltimore 7-748% -2½ -120BetRivers | |||||||
 Indianapolis 8-674% +6 -110Bet365 |
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