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The upcoming NFL matchup on December 28, 2025, between the Arizona Cardinals and Cincinnati Bengals at Paycor Stadium in Cincinnati, OH, is shaping up to be a thrilling Sunday football showdown. Both teams have had their struggles this season, but this game offers exciting betting trends to consider. The Bengals, led by starting quarterback Joe Burrow, have a slight edge in offensive production, averaging 23.93 points per game compared to the Cardinals' 21.4. Burrow's ability to navigate through the Cardinals' defense will be key, especially considering Arizona's strong pass defense that ranks well in interceptions and sacks.
Arizona's quarterback Kedon Slovis is expected to start, with some key players questionable but likely to play, including cornerback L.J. Collier and offensive lineman Kelvin Beachum. The Cardinals' offense, averaging 20.2 first downs per game, will test the Bengals' defense, which has allowed 22 points per game. The Bengals' defense is known for its pass rush, which may challenge Slovis's pass protection.
The betting odds favor Cincinnati with a -7 point spread and a total points line set at 53.5. This suggests the game might be high scoring, and bettors should watch the run offense vs. run defense dynamics closely, as both teams have solid rushing attacks but also vulnerabilities in run defense. The Bengals' recent 45-21 win over Miami shows their potential to cover spreads, while the Cardinals have struggled lately, losing several games, including a 26-19 loss to Atlanta.
For those looking for game insights and betting stats to make smart wagers, this game broadcasts on FOX, providing excellent coverage. The Bengals' home advantage at Paycor Stadium could be a deciding factor, and the team's ATS record of 3-4 at home versus the Cardinals' strong 5-2 ATS away suggests interesting betting angles. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.
In their last matchup on October 8, 2023, the Bengals defeated the Cardinals 34-20, a game full of action and betting excitement you can revisit for more context.
![]() Washington 4-1160% +7 -120BetRivers | |||||||
Minnesota 7-866% +6 -110Bet365 | |||||||
![]() Kansas City 6-973% +13 -110Bet365 | |||||||
![]() L.A. Chargers 11-448% -1½ -112BetRivers | |||||||
Green Bay 9-5-142% -2½ -105FanDuel | |||||||
![]() Cincinnati 5-1011% -7 -108BetRivers | |||||||
Carolina 8-764% +7½ -120FanDuel | |||||||
Cleveland 3-1282% +4 -108BetRivers | |||||||
![]() Tennessee 3-1265% +3 -118FanDuel | |||||||
Miami 6-994% +5½ -110Bet365 | |||||||
![]() Indianapolis 8-7- +6½ -104FanDuel | |||||||
![]() N.Y. Jets 3-12100% +13½ -110Bet365 | |||||||
![]() Las Vegas 2-1350% -1 -105BetMGM | |||||||
Buffalo 11-433% -2 -112Caesars | |||||||
![]() San Francisco 11-4100% -2½ -120BetRivers | |||||||
![]() Atlanta 6-987% +8½ -115Caesars |
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