Arizona Cardinals vs Green Bay Packers Betting Trends

The upcoming NFL showdown on October 19, 2025, between the Arizona Cardinals and Green Bay Packers at State Farm Stadium in Glendale, AZ, is generating buzz among football fans and bettors alike. This Sunday football game features a compelling clash of strengths and weaknesses that bettors should carefully analyze using betting trends and game insights.

The Cardinals, led by quarterback Kyler Murray who is questionable but likely to play despite a foot injury, face a Packers team starting Jordan Love at quarterback. Arizona's pass offense averages 193.8 yards per game against Green Bay's pass defense allowing 207.2 yards, indicating a nearly even matchup in the air. Meanwhile, Green Bay's pass offense is stronger, averaging 237.4 yards, facing a Cardinals defense that gives up 246 yards per game through the air. On the ground, the Packers' run offense is potent with 122.2 yards per game, challenging the Cardinals' run defense which allows 102 yards. Conversely, Arizona's run offense is decent at 113.2 yards, facing a Packers run defense that limits opponents to 73 yards.

Pass protection will be crucial as the Packers boast a solid offensive line, while the Cardinals have some questionable offensive linemen due to injuries. Green Bay's pass rush, though not overpowering, could exploit these weaknesses. The point spread favors Green Bay by 7 points with a total of 44.5 points, reflecting expectations of a moderately high-scoring game. These betting stats suggest a strategic bet on the Packers covering the spread while considering the over on total points.

Arizona's recent form includes a close loss to Indianapolis, while Green Bay is coming off a strong win against Cincinnati. The Packers have a 3-1-1 record straight up but struggle ATS on the road, while the Cardinals are 2-4-0 overall but winless ATS at home. The game will be broadcast on FOX, making it accessible for fans nationwide.

Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge. For odds and sportsbook reviews, check out Caesars. In their last matchup on October 13, 2024, where Green Bay won 34-13, the Packers dominated the Cardinals, setting the stage for this exciting rematch.