Betting Trends for Arizona Cardinals vs L.A. Rams Rams

The upcoming NFL showdown on January 4, 2026, features the Arizona Cardinals visiting the L.A. Rams Rams at SoFi Stadium in Inglewood, CA. This regular season Week 18 game promises to be an electrifying Sunday football clash in the 2025-26 NFL season, broadcast on FOX.

The Cardinals, led by starting quarterback Kyler Murray, face a tough challenge against the Rams, who will start Matthew Stafford under center. Arizona has struggled recently with a 3-13 straight-up record and 6-10 against the spread, but they perform better on the road with a 5-3 ATS record. The Rams boast a strong 11-5 straight-up record and 11-5 ATS, particularly dominant at home with a 6-1 SU and 5-2 ATS record.

Betting trends show the Rams as favorites with a -13.5 point spread and a total points line set at 47.5. The Rams’ offense excels with 269 passing yards per game and a solid 125 rushing yards, while the Cardinals’ defense allows 355 total yards per game, highlighting a potential advantage for the Rams’ passing attack. Conversely, the Cardinals’ offense averages 232 passing yards and 94 rushing yards, but the Rams’ defense is tougher, allowing only 328 total yards.

Pass protection for the Rams has been solid, which is crucial against the Cardinals’ pass rush led by key defensive players like Calais Campbell (though questionable in practice). The Cardinals’ pass defense ranks high in 1st downs allowed and interceptions but has been beaten in recent matchups, including a 45-17 loss to the Rams in their last meeting on December 7, 2025.

Injuries could influence the game, with Rams players like Blake Corum and Tyler Higbee listed as questionable. The Cardinals have some key defensive players at full participation, such as Budda Baker. These factors combine to suggest that the Rams are likely to control the pace and cover the spread.

For bettors, the 13.5-point spread and 47.5 total points line offer a strategic edge, especially given the Rams’ home dominance and offensive potency. The Rams' ability to protect their quarterback and exploit the Cardinals' defensive vulnerabilities makes them a strong pick.

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In their last matchup on December 7, 2025, where the Rams won 45-17, the Rams dominated the Cardinals, providing a preview of what to expect in this upcoming encounter.