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Nov 16, 2025 4:05 PM EST
Week 11
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-3 (-120)o48 (-120)
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Arizona Cardinals vs San Francisco 49ers Injury Report
Updated:Nov 15, 2025 2:26 AM EST
The upcoming NFL matchup on November 16, 2025, features the Arizona Cardinals vs San Francisco 49ers at State Farm Stadium in Glendale, AZ. This Sunday football game promises excitement as both teams navigate key player injuries that could impact the outcome. The 49ers face significant setbacks with several core players on injured reserve, including linebacker Fred Warner (ankle surgery), defensive lineman Nick Bosa (knee ACL surgery), and wide receiver Trent Taylor on IR with an undisclosed injury. Wide receiver Brandon Aiyuk remains on the Physically Unable to Perform-Reserve (PUP-R) list due to knee surgery, while defensive back Deommodore Lenoir is questionable with a calf injury. These absences could challenge San Francisco's defensive and offensive capabilities.
Meanwhile, the Arizona Cardinals are also managing critical injuries. Quarterback Kyler Murray is on injured reserve with a mid-foot sprain, unlikely to start if he returns this season. Key offensive linemen like Kelvin Beachum and Will Hernandez are questionable for the game, while running backs James Conner and Zonovan Knight are sidelined or doubtful. Multiple defensive players, including Justin Jones and L.J. Collier, are on injured reserve, limiting depth. The Cardinals' injury list also includes notable names like wide receiver Zay Jones and linebacker J.J. Russell on IR, as well as several players ruled out for the game.
These injury reports are essential for bettors aiming to make informed wagers. Understanding player statuses, especially the impact of missing starters or key substitutes, provides insight into team strengths and potential game dynamics. This information is crucial for evaluating betting lines and prop bets. Fans can catch the game live on FOX, making it a prime event for Sunday night football enthusiasts. For a comprehensive view of league-wide injuries, check out the NFL injury list to stay updated on player statuses and make smarter bets. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.
OFFENSE DEPTH CHART
QUARTERBACK
Player Name
CP/ATT
YDS
TD
INT
Brock
Purdy
Purdy
48/73
586
4
4
13 Quarterback
Mac
Jones
Jones
201/289
2151
13
6
10 Quarterback
Adrian
Martinez
Martinez
No information available
WIDE RECEIVER
Player Name
REC
YDS
TD
AVG
Jauan
Jennings
Jennings
28-50
324
3
11.6
15 Wide Receiver
Ricky
Pearsall
Pearsall
20-29
327
0
16.4
1 Wide Receiver
Kendrick
Bourne
Bourne
31-42
482
0
15.5
84 Wide Receiver
Jordan
Watkins
Watkins
2-3
26
0
13.0
17 Wide Receiver
Demarcus
Robinson
Robinson
11-21
142
0
12.9
5 Wide Receiver
Skyy
Moore
Moore
4-6
64
0
16.0
9 Wide Receiver
LEFT TACKLE
Player Name
GS
G
P
PY
Trent
Williams
Williams
10
10
2
25
71 Offensive Tackle
CENTER
Player Name
GS
G
P
PY
Jake
Brendel
Brendel
8
8
3
26
64 Offensive Line
Matt
Hennessy
Hennessy
2
10
0
0
61 Offensive Line
RIGHT TACKLE
Player Name
GS
G
P
PY
Colton
McKivitz
McKivitz
10
10
5
30
68 Offensive Line
Austen
Pleasants
Pleasants
0
8
0
0
62 Offensive Line
RUNNING BACK
Player Name
CAR
YDS
TD
AVG
Kyle
Juszczyk
Juszczyk
2
-3
0
-1.5
44 Fullback
Christian
McCaffrey
McCaffrey
180
626
4
3.5
23 RB
Brian
Robinson Jr.
Robinson Jr.
49
238
2
4.9
3 Running Back
Isaac
Guerendo
Guerendo
No information available
31 Running Back
Jordan
James
James
No information available
29 Running Back
TIGHT END
Player Name
REC
YDS
TD
AVG
George
Kittle
Kittle
21-24
184
3
8.8
85 Tight End
Luke
Farrell
Farrell
10-12
82
2
8.2
89 Tight End
Jake
Tonges
Tonges
26-35
226
4
8.7
88 Tight End
LEFT GUARD
Player Name
GS
G
P
PY
Ben
Bartch
Bartch
2
3
0
0
78 Offensive Line
Spencer
Burford
Burford
2
4
0
0
74 Offensive Line
RIGHT GUARD
Player Name
GS
G
P
PY
Dominick
Puni
Puni
10
10
2
10
77 Offensive Line
Connor
Colby
Colby
6
9
3
20
75 Offensive Line
DEFENSE DEPTH CHART
LEFT END
Player Name
T-A
SACK
TFL
TD
Bryce
Huff
Huff
11-8
4
6
0
47 Defensive Line
Robert
Beal Jr.
Beal Jr.
1-6
0
0
0
51 Defensive Line
DEFENSIVE TACKLE
Player Name
T-A
SACK
TFL
TD
Alfred
Collins
Collins
2-6
0
0
0
95 Defensive Tackle
Kalia
Davis
Davis
7-10
0.5
3
0
93 Defensive Line
Kevin
Givens
Givens
1-1
0
0
0
90 Defensive Line
Jordan
Elliott
Elliott
5-16
0
1
0
92 Defensive Line
C.J.
West
West
4-3
0
0
0
99 Defensive Tackle
LEFT CORNERBACK
Player Name
INT
YDS
PD
TD
Renardo
Green
Green
0
0
8
0
0 Cornerback
Darrell
Luter Jr.
Luter Jr.
No information available
28 Cornerback
SAFETY
Player Name
INT
YDS
PD
TD
Ji'Ayir
Brown
Brown
0
0
3
0
27 Safety
Malik
Mustapha
Mustapha
No information available
6 Safety
Jason
Pinnock
Pinnock
No information available
25 Safety
Marques
Sigle
Sigle
0
0
2
0
36 Safety
RIGHT END
Player Name
T-A
SACK
TFL
TD
Sam
Okuayinonu
Okuayinonu
15-13
2
3
0
91 Defensive Line
Keion
White
White
0
0.5
0
0
56 Defensive Line
LINEBACKER
Player Name
T-A
SACK
TFL
TD
Dee
Winters
Winters
47-20
0
5
0
53 Linebacker
Upton
Stout
Stout
24-20
1
3
0
20 Cornerback
Tatum
Bethune
Bethune
23-38
0
2
0
48 Linebacker
Curtis
Robinson
Robinson
4-3
0
1
0
59 Linebacker
Chase
Lucas
Lucas
No information available
26 Cornerback
Luke
Gifford
Gifford
3-7
0
0
0
57 Linebacker
Nick
Martin
Martin
No information available
45 Linebacker
RIGHT CORNERBACK
Player Name
INT
YDS
PD
TD
Deommodore
Lenoir
Lenoir
1
26
3
0
Questionable
Siran
Neal
Neal
No information available
33 Cornerback
SPECIAL TEAMS DEPTH CHART
KICKER
Player Name
FG
LONG
XP
PTS
Eddy
Pineiro
Pineiro
19
59
16
73
18 Kicker
PUNTER
Player Name
PUNTS
AVG
I20
LONG
Thomas
Morstead
Morstead
29
44.8
15
54
7 Punter
HOLDER
Player Name
Thomas
Morstead
Morstead
7 Punter
KICK RETURNER
Player Name
RET
AVG
TD
LONG
Brian
Robinson Jr.
Robinson Jr.
6
32.0
0
46
3 Running Back
Skyy
Moore
Moore
20
25.1
0
38
9 Wide Receiver
Isaac
Guerendo
Guerendo
5
20.0
0
25
31 Running Back
PUNT RETURNER
Player Name
RET
AVG
TD
LONG
Skyy
Moore
Moore
17
10.4
0
27
9 Wide Receiver
Jordan
Watkins
Watkins
No information available
17 Wide Receiver
Ricky
Pearsall
Pearsall
No information available
1 Wide Receiver
LONG SNAPPER
Player Name
Jon
Weeks
Weeks
46 Long Snapper
Additional Injuries
Brandon Aiyuk
11 Wide Receiver
5 days ago
PUP
Est. Return Nov 24, 2025
Coach Kyle Shanahan said Monday that the 49ers don't intend to open Aiyuk's (knee) practice window this week, Nick Wagoner of ESPN.com reports. More Details
Trent Taylor
81 Wide Receiver
5 months ago
Injury Reserve
Est. Return Feb 9, 2026
The 49ers placed Taylor (undisclosed) on injured reserve Tuesday. More Details
Fred Warner
54 Linebacker
a month ago
Injury Reserve
Est. Return Feb 9, 2026
The 49ers placed Warner (ankle) on injured reserve Saturday. More Details
Nick Bosa
97 Defensive Line
2 months ago
Injury Reserve
Est. Return Feb 9, 2026
Bosa (knee) underwent surgery to address his torn ACL on Friday, Cam Inman of The San Jose Mercury News reports. More Details
Yetur Gross-Matos
94 Defensive Line
14 days ago
Injury Reserve
Est. Return Nov 30, 2025
Gross-Matos (knee) was placed on injured reserve Saturday. More Details
Patrick Taylor Jr.
32 Running Back
3 months ago
Injury Reserve
Est. Return Feb 9, 2026
Taylor will undergo season-ending surgery to repair a fracture in his shoulder, Nick Wagoner of ESPN.com reports. More Details
Tre Tomlinson
35 Cornerback
6 months ago
Injury Reserve
Est. Return Feb 9, 2026
Tomlinson (undisclosed) reverted to the 49ers' injured reserve Tuesday, per the NFL's transaction log. More Details
Jacob Cowing
19 Wide Receiver
a month ago
Injury Reserve
Est. Return Nov 16, 2025
Head coach Kyle Shanahan said Friday that Cowing (hamstring) is "getting close" to returning from injured reserve, Nick Wagoner of ESPN.com reports. More Details
Mykel Williams
98 Defensive Line
7 days ago
Injury Reserve
Est. Return Feb 9, 2026
The 49ers placed Williams (knee) on injured reserve Saturday. More Details
Jakob Robinson
49 Cornerback
3 months ago
Injury Reserve
Est. Return Feb 9, 2026
Robinson (forearm) was placed on injured reserve Tuesday. More Details
Kurtis Rourke
4 Quarterback
3 months ago
NFI-R
Est. Return Nov 16, 2025
Rourke (knee) was placed on the reserve/non-football injury list Tuesday. More Details
Tarron Jackson
56 Defensive Line
4 months ago
Injury Reserve
Est. Return Feb 9, 2026
The 49ers placed Jackson (undisclosed) on injured reserve Tuesday. More Details
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NFLWeek 11
 Miami 3-763% -2½ -110FanDuel | |||||||
 N.Y. Giants 2-881% +7½ -120FanDuel | |||||||
 Buffalo 6-339% -5½ -120FanDuel | |||||||
 Pittsburgh 5-441% -5½ -108FanDuel | |||||||
 Tennessee 1-851% +6½ -118SugarHouse | |||||||
 Minnesota 4-541% -2 -125BetMGM | |||||||
 Atlanta 3-645% -3½ -105Bet365 | |||||||
 Jacksonville 5-446% +3 -115Caesars | |||||||
 L.A. Rams 7-250% -3 -120Bet365 | |||||||
 Arizona 3-674% +3½ -110Caesars | |||||||
 Cleveland 2-765% +8 -117SugarHouse | |||||||
 Denver 8-277% +4 -105BetMGM | |||||||
 Philadelphia 7-269% -2½ -115BetRivers | |||||||
 Las Vegas 2-793% +3½ -112BetRivers | |||||||
 New England 9-227 -12½ -110FanDuel |
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