Player Props Arizona Cardinals vs San Francisco 49ers

The upcoming Sunday football game on November 16, 2025, between the Arizona Cardinals and San Francisco 49ers at State Farm Stadium in Glendale, AZ, offers an exciting NFL matchup for bettors and fans alike. Broadcasted on Fox, this game is packed with intriguing player props and prop bets, especially focusing on key players' receiving yards, rushing yards, and passing yards.

The Arizona Cardinals face the San Francisco 49ers in a contest where passing offense meets strong pass defense, creating a strategic battle on the field. Arizona's Greg Dortch and Michael Wilson have under projections on receiving yards and receptions, reflecting the Cardinals' cautious aerial approach. Meanwhile, San Francisco's Christian McCaffrey is a standout with high expected value (EV) and hit rate on his total rushing and receiving yards over 129.5, making him a prime target for player props bettors.

Comparing run offenses, the 49ers' powerful rushing attack contrasts with the Cardinals' run defense, which could influence rushing yards prop bets. Additionally, San Francisco's pass protection versus Arizona's pass rush will be a key factor in the game's tempo and scoring opportunities. Our player projections have performed well over the last 10 games, particularly in markets like total yards and receptions, offering bettors valuable insights.

For those looking to make smart betting decisions, understanding these dynamics and the pace of play is crucial. Check out the detailed NFL player props for this season to find more profitable bets. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.