Arizona Cardinals vs San Francisco 49ers Weather

As the Arizona Cardinals prepare to visit the San Francisco 49ers on September 21, 2025, at Levi's Stadium in Santa Clara, CA, the stakes are high for this thrilling NFL matchup. The 49ers, playing in front of a home crowd, are looking to maintain their strong record at home where they have thrived, especially in clear weather conditions. Historically, the 49ers have shown resilience in such conditions, while the Cardinals have struggled on the road in similar settings. The game, airing on Fox, promises clear skies with temperatures around 80°F and minimal wind, which should favor the 49ers' passing game. The Cardinals will need to adapt quickly to these weather conditions to stand a chance. With a slight chance of rain and no snow in the forecast, the weather seems set to play a minimal role, allowing both teams to focus on their strategies. For bettors, understanding the impact of weather and home-field advantage could be crucial. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge. Check out the NFL weather page for more insights.