Dec 7, 2025 1:00 PM EST

Week 14

Cincinnati

8-4

Buffalo

BUF

-5½ (-112)o53½ (-108)

FOX

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Cincinnati Bengals vs Buffalo Bills Picks

Updated:Dec 4, 2025 1:25 AM EST

The upcoming NFL showdown on December 7, 2025, features the Cincinnati Bengals facing off against the Buffalo Bills at Highmark Stadium in Orchard Park, NY. This Sunday football game promises exciting action and competitive spirit as both teams look to gain crucial wins in the 2025-26 season. The game will be broadcast on FOX, giving fans nationwide a chance to catch all the live action.

Our expert picks for this Bengals vs Bills matchup predict a close contest, with Buffalo edging out Cincinnati 28-25 on the moneyline and a spread of Bills -5.5. The predicted total score is approximately 53.4 points, indicating a potentially high-scoring affair that aligns closely with the over/under line set at 52.5. Our prediction model has been profitable in recent games, especially with the American Total market, boasting a hit rate of 56.3% and a positive EV of 3.9%, which bettors can leverage for smart wagering decisions.

For bettors looking to make informed choices, these picks and betting tips provide valuable insights into likely outcomes and betting angles. Explore more detailed NFL picks and predictions to enhance your betting strategy and maximize your potential returns. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.

Which team is favored in the betting lines?

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ODDS PICKS PLAYER PROPS FUTURES PLAYER FUTURES INJURIES WEATHER RANKINGS STANDINGS

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Personalize your notifications and get updates on the teams, players or events you care about most. THU 12/048:15 PM Dallas 6-5-1 54% +3 -105Bet365
Detroit 7-5 46% -3 -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/071:00 PM Washington 3-9 50% +2 -110Bet365
Minnesota 4-8 50% -1½ -112FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/071:00 PM Miami 5-7 28% -2½ -113Caesars
N.Y. Jets 3-9 72% +3 -118BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/071:00 PM Tennessee 1-11 90% +4 -109BetRivers
Cleveland 3-9 10% -3½ -122FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/071:00 PM Pittsburgh 6-6 66% +6 -110Bet365
Baltimore 6-6 34% -5½ -115FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/071:00 PM Seattle 9-3 16% -7 -105Bet365
Atlanta 4-8 84% +7 -108FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/071:00 PM Indianapolis 8-4 34% -1½ -110Bet365
Jacksonville 8-4 66% +1½ -107Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/071:00 PM New Orleans 2-10 90% +8½ -108FanDuel
Tampa Bay 7-5 10% -8½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/071:00 PM Cincinnati 4-8 64% +5½ -105FanDuel
Buffalo 8-4 36% -5½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/074:05 PM Denver 10-2 16% -7½ -110Caesars
Las Vegas 2-10 84% +7½ -105BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/074:25 PM Chicago 9-3 47% +6½ -105Bet365
Green Bay 8-3-1 53% -6½ -110BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/074:25 PM L.A. Rams 9-3 10% -8 -110Caesars
Arizona 3-9 90% +8½ -114BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/078:20 PM Houston 7-5 73% +3½ -113Caesars
Kansas City 6-6 27% -3 -120Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. MON 12/088:15 PM Philadelphia 8-4 28% -2½ -120Bet365
L.A. Chargers 8-4 72% +3 -110Caesars

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