Buffalo Bills vs Denver Broncos Betting Trends

The highly anticipated Saturday football showdown on January 17, 2026, features the Buffalo Bills visiting the Denver Broncos at Empower Field at Mile High in Denver, CO. This NFL matchup promises thrilling action as both teams look to advance their playoff aspirations in the 2025-26 NFL season. The Bills, led by starting quarterback Josh Allen, who is fully healthy and practiced, bring a potent offensive attack averaging 376.3 yards per game, with a balanced run and pass game. Denver counters with quarterback Jarrett Stidham, who steps in for the Broncos, providing a different dynamic but with less experience than Allen.

Buffalo's offense boasts a strong pass offense facing Denver's pass defense, which allows roughly 187 passing yards per game, making this a key matchup to watch. Denver's run offense is solid, averaging 118.7 rushing yards per game, but they face a tough Bills run defense that yields just 136.2 rushing yards. Pass protection versus pass rush is another critical battle, with Buffalo's offensive line showing strength against a Denver defense that averages over 24 sacks per season.

The betting trends indicate Buffalo as the favorite with a spread of -1.5 and total points set at 46. The Bills have a balanced record ATS (9-9), while Denver holds a 7-10 ATS record. The game is broadcast on CBS, providing fans and bettors with convenient access to the action. Injuries are minimal, with key players like Buffalo's Matt Prater questionable but likely to play, and Denver's lineup intact. These betting insights and game stats are crucial for making informed wagers. For the best odds, the Bills are available at BetOnline. Don't miss the chance to check out the detailed betting trends for this exciting NFL matchup and place your bets with confidence.

In their January 12, 2025, matchup, the Bills dominated the Broncos 31-7 at Highmark Stadium, a result that adds context to this upcoming contest.