Jan 17, 2026 4:30 PM EST

Division

Buffalo

14-3

Denver

DEN

-1½ (-107)o46 (-105)

CBS

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Buffalo Bills vs Denver Broncos Picks and Predictions

Updated:Jan 17, 2026 1:21 AM EST

The upcoming NFL showdown on January 17, 2026, features the Buffalo Bills visiting the Denver Broncos at Empower Field at Mile High in Denver, CO. This Saturday football matchup promises to be a thrilling contest broadcast live on CBS, offering bettors exciting opportunities to capitalize on expert insights and betting tips.

Our latest picks for Buffalo Bills vs Denver Broncos highlight a closely contested game with a predicted score of 25-23 in favor of Buffalo. The Bills are favored at +1.5 on the point spread with a 59.1% cover percentage and a positive expected value (EV) of 6.7%, indicating a profitable betting market. The total points are expected to go over 46, with a predicted total score near 47.6, supported by a 53.1% coverage rate and an EV of 2.4%.

Our prediction model has performed well in recent NFL games, boasting a high hit rate on point spread and total bets, making these picks reliable for bettors seeking value. Understanding these stats can help you make informed wagers and increase your chances of winning. Check out our detailed NFL picks and predictions to stay ahead of the game and place smart bets with confidence.

Don't miss the Buffalo Bills vs Denver Broncos game this Saturday at Empower Field at Mile High. Tune in to CBS and use our expert picks to maximize your betting success. For more insights and to explore all NFL betting options, visit our comprehensive NFL picks and predictions page.

What are the expert picks for this game?

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ODDS PICKS PLAYER PROPS FUTURES PLAYER FUTURES INJURIES WEATHER RANKINGS STANDINGS

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Personalize your notifications and get updates on the teams, players or events you care about most. SAT 01/174:30 PM Buffalo 13-5 41% +1½ -110Everygame
Denver 14-3 59% -1 -108Heritage
Personalize your notifications and get updates on the teams, players or events you care about most. SAT 01/178:00 PM San Francisco 13-5 48% +7½ -115BetOnline
Seattle 14-3 52% -7 -108Heritage
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 01/183:00 PM Houston 13-5 44% +3½ -120BetOnline
New England 15-3 56% -3 -118Heritage
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 01/186:30 PM L.A. Rams 13-5 38% -3½ -115BetOnline
Chicago 12-6 62% +4 -105Bookmaker

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