Nov 20, 2025 8:15 PM EST

Week 12

Buffalo

5-5

Houston

BUF

-6 (-110)o43½ (-115)

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Buffalo Bills vs Houston Texans Odds for NFL Week 12

Updated:Nov 20, 2025 1:12 AM EST

The upcoming clash on November 20, 2025, between the Buffalo Bills and Houston Texans at NRG Stadium in Houston, TX, is a highly anticipated Thursday night football event in the NFL. This game offers intriguing odds and betting lines that bettors should carefully consider to make smart wagers. The Bills are favored with a point spread of -6 -110, indicating they are expected to win by at least six points. The Texans, as underdogs, have a +6 -109 spread, which could attract bettors looking for value.

Opening odds showed a more balanced scenario, but the current odds favor the Bills more strongly, reflecting recent betting trends and team performance insights. The total points line is set at 43.5 with the over at -110 and the under at -109, providing additional betting options for totals enthusiasts. This game will be broadcast on Amazon Prime Video, making it accessible for fans and bettors alike.

Understanding these odds, including the point spread and totals, can help bettors evaluate the potential outcomes and place informed bets. For those looking to dive deeper into NFL betting strategies, checking the latest NFL odds page can provide valuable context and updates. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.

What is the best bet for the Buffalo Bills vs Houston Texans game?

Spread (FULL GAME)

EXPECTED VALUECOVER PROB.EXPECTED VALUEBEST LINE

BuffaloSpread

+0.2%

HoustonSpread

-5.9%

MONEYLINE (FULL GAME)

EXPECTED VALUECOVER PROB.EXPECTED VALUEBEST LINE

BuffaloMONEYLINE

-0.1%

HoustonMONEYLINE

-3.5%

EXCLUSIVE BOOSTS

Khalil Shakir & Dalton Schultz Each Score TDKhalil Shakir & Dalton Schultz Each Score TD

Woody Marks First TD Scorer in Bills @ Texans GameWoody Marks First TD Scorer in Bills @ Texans Game

Nico Collins Over 89.5 Receiving Yards & TDNico Collins Over 89.5 receiving yards & to score a touchdown

6 Total BoostsFor This Event

Total (FULL GAME)

EXPECTED VALUECOVER PROB.EXPECTED VALUEBEST LINE

OVERTotal

-5.7%

UNDERTotal

-0.8%

Spread (1H)

BEST LINE

BuffaloSpread

HoustonSpread

MONEYLINE (1H)

BEST LINE

BuffaloMONEYLINE

HoustonMONEYLINE

Total (1H)

BEST LINE

OVERTotal

UNDERTotal

Spread (2H)

BEST LINE

BuffaloSpread

HoustonSpread

MONEYLINE (2H)

BEST LINE

BuffaloMONEYLINE

HoustonMONEYLINE

DRAWMONEYLINE

Total (2H)

BEST LINE

OVERTotal

UNDERTotal

Spread (1Q)

BEST LINE

BuffaloSpread

HoustonSpread

MONEYLINE (1Q)

BEST LINE

BuffaloMONEYLINE

HoustonMONEYLINE

Total (1Q)

BEST LINE

OVERTotal

UNDERTotal

Spread (2Q)

BEST LINE

BuffaloSpread

HoustonSpread

MONEYLINE (2Q)

BEST LINE

BuffaloMONEYLINE

HoustonMONEYLINE

Total (2Q)

BEST LINE

OVERTotal

UNDERTotal

Spread (3Q)

BEST LINE

BuffaloSpread

HoustonSpread

MONEYLINE (3Q)

BEST LINE

BuffaloMONEYLINE

HoustonMONEYLINE

Total (3Q)

BEST LINE

OVERTotal

UNDERTotal

Spread (4Q)

BEST LINE

BuffaloSpread

HoustonSpread

MONEYLINE (4Q)

BEST LINE

BuffaloMONEYLINE

HoustonMONEYLINE

Total (4Q)

BEST LINE

OVERTotal

UNDERTotal

The best odds available today for Buffalo is -5½ -122 at FanDuel and for Houston +6 -109 at Caesars. The total for the over/under line is o43½ -108 at FanDuel.

NFL

ODDS PICKS PLAYER PROPS FUTURES PLAYER FUTURES INJURIES WEATHER RANKINGS STANDINGS

Spread

Spread
Money
Total
Merged

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Game
1H
2H
1Q
2Q
3Q
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This Week

Last Week

Personalize your notifications and get updates on the teams, players or events you care about most. THU 11/208:15 PM Buffalo 7-3 28% -5½ -122FanDuel
Houston 5-5 72% +6 -109Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/231:00 PM Pittsburgh 6-4 44% +3 -120BetRivers
Chicago 7-3 56% -2½ -114Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/231:00 PM N.Y. Jets 2-8 84% +14 -115Bet365
Baltimore 5-5 16% -13½ -108Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/231:00 PM N.Y. Giants 2-9 95% +11 -114BetRivers
Detroit 6-4 5% -10½ -102FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/231:00 PM New England 9-2 28% -7 -115Caesars
Cincinnati 3-7 72% +7½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/231:00 PM Seattle 7-3 16% -12½ -110Bet365
Tennessee 1-9 84% +13½ -110BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/231:00 PM Minnesota 4-6 83% +6½ -110Caesars
Green Bay 6-3-1 17% -6½ -109Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/231:00 PM Indianapolis 8-2 73% +3½ -114Caesars
Kansas City 5-5 27% -3½ -102BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/234:05 PM Jacksonville 6-4 43% -2½ -112FanDuel
Arizona 3-7 57% +3 -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/234:05 PM Cleveland 2-8 38% +4 -109BetRivers
Las Vegas 2-8 62% -3½ -118FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/234:25 PM Atlanta 3-7 33% +1½ -108Caesars
New Orleans 2-8 67% +1 -115Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/234:25 PM Philadelphia 8-2 46% -3 -113Caesars
Dallas 4-5-1 54% +3½ -115BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/238:20 PM Tampa Bay 6-4 64% +6½ -102FanDuel
L.A. Rams 8-2 36% -6½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. MON 11/248:15 PM Carolina 6-5 91% +7 -109Caesars
San Francisco 7-4 9% -6½ -115Bet365

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