Nov 20, 2025 8:15 PM EST

Week 12

Buffalo

5-5

Houston

BUF

-6 (-110)o43½ (-115)

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Buffalo Bills vs Houston Texans Picks

Updated:Nov 20, 2025 1:15 AM EST

The upcoming NFL Thursday night football game on November 20, 2025, features the Buffalo Bills visiting the Houston Texans at NRG Stadium in Houston, TX. This game promises to be an exciting matchup as both teams vie for a critical Week 12 victory. Broadcasted on Amazon Prime Video, fans and bettors alike will be glued to their screens for this thrilling contest.

Our expert picks and predictions favor the Buffalo Bills to win this clash with a predicted score of 25-18 against the Houston Texans. The Bills are favored by 6 points on the spread, and our betting tips suggest that backing Buffalo on the moneyline is a smart play. Recent prediction models have shown a strong hit rate, especially on the 2-way moneyline market, with a 73.6% cover percentage and a positive expected value (EV) of -0.1%, indicating a profitable betting edge.

Additionally, the total points are expected to fall under 43.5, supported by a 50.5% hit rate in recent games, aligning well with our predicted total of approximately 43. This insight can help bettors make more informed decisions, especially when considering parlays and other betting strategies.

For those looking to dive deeper into NFL betting, check out our detailed NFL picks page for more insights and expert analysis. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.

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ODDS PICKS PLAYER PROPS FUTURES PLAYER FUTURES INJURIES WEATHER RANKINGS STANDINGS

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Personalize your notifications and get updates on the teams, players or events you care about most. THU 11/208:15 PM Buffalo 7-3 28% -5½ -122FanDuel
Houston 5-5 72% +6 -109Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/231:00 PM Pittsburgh 6-4 44% +3 -120BetRivers
Chicago 7-3 56% -2½ -114Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/231:00 PM N.Y. Jets 2-8 84% +14 -115Bet365
Baltimore 5-5 16% -13½ -108Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/231:00 PM N.Y. Giants 2-9 95% +11 -114BetRivers
Detroit 6-4 5% -10½ -102FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/231:00 PM New England 9-2 28% -7 -115Caesars
Cincinnati 3-7 72% +7½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/231:00 PM Seattle 7-3 16% -12½ -110Bet365
Tennessee 1-9 84% +13½ -110BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/231:00 PM Minnesota 4-6 83% +6½ -110Caesars
Green Bay 6-3-1 17% -6½ -109Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/231:00 PM Indianapolis 8-2 73% +3½ -114Caesars
Kansas City 5-5 27% -3½ -102BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/234:05 PM Jacksonville 6-4 43% -2½ -112FanDuel
Arizona 3-7 57% +3 -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/234:05 PM Cleveland 2-8 38% +4 -109BetRivers
Las Vegas 2-8 62% -3½ -118FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/234:25 PM Atlanta 3-7 33% +1½ -108Caesars
New Orleans 2-8 67% +1 -115Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/234:25 PM Philadelphia 8-2 46% -3 -113Caesars
Dallas 4-5-1 54% +3½ -115BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/238:20 PM Tampa Bay 6-4 64% +6½ -102FanDuel
L.A. Rams 8-2 36% -6½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. MON 11/248:15 PM Carolina 6-5 91% +7 -109Caesars
San Francisco 7-4 9% -6½ -115Bet365

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