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The upcoming NFL Thursday night football game on November 20, 2025, features the Buffalo Bills visiting the Houston Texans at NRG Stadium in Houston, TX. This game promises to be an exciting matchup as both teams vie for a critical Week 12 victory. Broadcasted on Amazon Prime Video, fans and bettors alike will be glued to their screens for this thrilling contest.
Our expert picks and predictions favor the Buffalo Bills to win this clash with a predicted score of 25-18 against the Houston Texans. The Bills are favored by 6 points on the spread, and our betting tips suggest that backing Buffalo on the moneyline is a smart play. Recent prediction models have shown a strong hit rate, especially on the 2-way moneyline market, with a 73.6% cover percentage and a positive expected value (EV) of -0.1%, indicating a profitable betting edge.
Additionally, the total points are expected to fall under 43.5, supported by a 50.5% hit rate in recent games, aligning well with our predicted total of approximately 43. This insight can help bettors make more informed decisions, especially when considering parlays and other betting strategies.
For those looking to dive deeper into NFL betting, check out our detailed NFL picks page for more insights and expert analysis. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.
![]() Houston 5-572% +6 -109Caesars | |||||||
![]() Chicago 7-356% -2½ -114Caesars | |||||||
![]() Baltimore 5-516% -13½ -108Caesars | |||||||
Detroit 6-45% -10½ -102FanDuel | |||||||
![]() Cincinnati 3-772% +7½ -110Bet365 | |||||||
![]() Tennessee 1-984% +13½ -110BetMGM | |||||||
Green Bay 6-3-117% -6½ -109Caesars | |||||||
![]() Kansas City 5-527% -3½ -102BetMGM | |||||||
Arizona 3-757% +3 -110Caesars | |||||||
![]() Las Vegas 2-862% -3½ -118FanDuel | |||||||
New Orleans 2-867% +1 -115Bet365 | |||||||
Dallas 4-5-154% +3½ -115BetMGM | |||||||
![]() L.A. Rams 8-236% -6½ -110Bet365 | |||||||
![]() San Francisco 7-49% -6½ -115Bet365 |
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