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FINAL
Nov 2, 2025 4:25 PM EST
KC 21 vs BUF 28
Week 9
KC
-2½ (-105)o53 (-110)
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Kansas City Chiefs vs Buffalo Bills Betting Trends
Updated:Nov 1, 2025 2:27 AM EDT
The upcoming NFL showdown on November 2, 2025, between the Kansas City Chiefs and the Buffalo Bills at Highmark Stadium in Orchard Park, NY, promises to be a thrilling Sunday football event. Both teams bring strong offensive and defensive stats into this Week 9 regular season clash, broadcast live on CBS. The Chiefs, led by star QB Patrick Mahomes, are favored with a -2 point spread and odds of -134 at Caesars, while the Bills, starting Josh Allen, are underdogs at +2 with +110 odds.
Buffalo's offense averages 382.9 total yards per game with a balanced attack including 218.4 passing yards and 164.4 rushing yards, while their defense allows 277.8 yards per game. Kansas City's offense is potent as well, averaging 378.3 yards, with a passing emphasis of 251.8 yards and a solid 126.5 rushing yards, against a defense giving up 312.1 yards. The Chiefs' pass protection faces a tough Bills pass rush, especially with Buffalo's defensive ends A.J. Epenesa and Matt Milano active, while the Bills' offensive line will need to hold strong against Chris Jones and the Chiefs' defensive front.
Buffalo has key injuries including DT DaQuan Jones (out) and WR Joshua Palmer (out), but QB Allen is healthy, which is crucial in this high-stakes game. Kansas City will miss RB Isiah Pacheco (out) and OT Josh Simmons (out), but Mahomes is fully fit. The game total is set at 52.5 points, with the under slightly favored at -110 odds.
Betting trends show the Chiefs have a 5-3 record ATS and the Bills 3-4 ATS, indicating a competitive matchup. Recent games suggest a lower scoring affair could be likely, but the dynamic offenses keep it unpredictable. For a smart wager, consider the Chiefs covering the -2 spread given their home advantage and Mahomes' elite playmaking.
In their last matchup on January 26, 2025, the Chiefs edged the Bills 32-29 in a close game, which you can review in detail on our January 26, 2025, game summary page. The Bills hold a strong home record, visible on our NFL standings page, which adds to the intrigue of this Sunday night football battle.
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ATS Records
All
6-11 (28th)Against the Spread9-10 (18th)
6-11 (24th)Straight Up13-6 (6th)
-8.0Straight Up Units+0.4
4-13Over / Under10-8-1
TEAM MATCHUP
OFF
DEF
OFF
DEF
21.3Points28.3
10.1First Half12.4
11.2Second Half15.9
3.1First Quarter5
6.9Second Quarter7.4
4.7Third Quarter7.1
6.4Fourth Quarter8.9
320.6Total Yards376.3
5.5Yards Per Play6.5
214.1Passing Yards216.6
21.4 - 34.4 (62.2%)Completions-Attempts20.2 - 29.1 (69.5%)
5.8Yards Per Passing Play6.9
2.8 (18)Sacks (Yards)2.4 (18)
106.6Rushing Yards159.6
25.3Attempts32.2
4.2Yards Per Rush5
19.81st Downs22
11.1Passing11.5
7.2Rushing8.6
1.5Penalties1.9
4.8 / 12.9 (37.4%)3rd Down5.5 / 12.4 (44.8%)
1.4 / 1.9 (75%)4th Down1.1 / 1.9 (59.4%)
2 / 3.5 (57.6%)Red Zone2.5 / 3.8 (66.2%)
7 (55.9)Penalties (Yards)5.9 (49.9)
0.8Turnovers1.3
0.6Interceptions0.8
0.2Fumbles Lost0.5
62.4Total Plays63.6
5.1Kickoffs5.6
3.9Returns3.9
101.6Return Yards108.4
26.2Yards Per Return27.9
3.3Punts2.9
1.9Returns1.8
15.2Return Yards11.4
8.1Yards Per Return6.5
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