- All
- 1st half
- 2nd half
- 1st quarter
- 2nd quarter
- 3rd quarter
- 4th quarter
The upcoming clash between the New England Patriots and Buffalo Bills on October 5, 2025, at Highmark Stadium in Orchard Park, NY, is shaping up to be an electrifying contest in the NFL. The Patriots, led by quarterback Drake Maye, are looking to capitalize on their recent momentum after a decisive victory over the Carolina Panthers. New England's offensive line has shown strength in pass protection, which will be crucial against Buffalo's formidable pass rush led by Ed Oliver, who is questionable but likely to play. The Bills, with Josh Allen at the helm, boast a robust pass offense that will test the Patriots' secondary, especially with Tre'Davious White anchoring the defense. Buffalo's home record is strong, as seen on our NFL standings page. The current spread sits at Buffalo -8, with a total point line of 48.5. These odds suggest a close game, but Buffalo's offensive firepower might just give them the edge. Catch the action on NBC and make informed bets with our Start your OddsTrader Turbo subscription.
Ready to bet smarter? Caesars offers the best odds with Buffalo as favorites at -420. Don't miss out on the action!
Cleveland 1-363% +3½ -110BetMGM | |||||||
Carolina 1-363% +1½ -110BetRivers | |||||||
![]() N.Y. Jets 0-477% +1½ -105FanDuel | |||||||
![]() Indianapolis 3-131% -7 -110FanDuel | |||||||
Philadelphia 4-033% -4 -110Caesars | |||||||
New Orleans 0-449% -1½ -110BetMGM | |||||||
![]() Baltimore 1-333% +2 -120BetMGM | |||||||
Arizona 2-232% -7½ -109BetRivers | |||||||
Seattle 3-165% -3½ -110Caesars | |||||||
![]() Cincinnati 2-284% +10½ -114BetRivers | |||||||
![]() L.A. Chargers 3-142% -2½ -120FanDuel | |||||||
Buffalo 4-022% -8 -105Caesars | |||||||
Jacksonville 3-183% +3½ -115Caesars | |||||||
![]() L.A. Rams 3-223 -7½ -115FanDuel |
OddsTrader uses cookies to help us provide, protect & improve our services. See ourPrivacy Policyfor more details.
ACCEPT & CLOSE