Buffalo Bills vs Pittsburgh Steelers Betting Trends

The upcoming NFL clash on November 30, 2025, between the Buffalo Bills and Pittsburgh Steelers at Acrisure Stadium in Pittsburgh, PA, promises an exciting Sunday football showdown. The Buffalo Bills, led by starting quarterback Josh Allen, bring a strong offensive game averaging 234.6 passing yards and 147.2 rushing yards per game. Meanwhile, the Steelers, with Mason Rudolph likely starting at quarterback given Aaron Rodgers' questionable status, offer a robust defense allowing just 258.7 passing yards and 105.7 rushing yards per game.

Buffalo's pass offense will challenge Pittsburgh's pass defense, while Pittsburgh's run defense faces a solid Bills rushing attack. Pittsburgh's pass rush, averaging 3.1 sacks per game, will test Buffalo's pass protection. Injuries could impact the game, with Buffalo's Maxwell Hairston and DaQuan Jones listed as questionable, while Pittsburgh's Joey Porter Jr. and Alex Highsmith also carry doubts.

The point spread favors the Bills by 3.5 points with a total points line set at 46.5. This spread reflects Buffalo's slightly better recent form, with a 7-4 straight-up record and 5-6 ATS, while the Steelers are 6-5 straight-up and 5-6 ATS. Both teams have shown trends toward under totals recently, aligning with the under 46.5 points line.

In their last matchup on August 17, 2024, the Bills defeated the Steelers 9-3 in a preseason game, highlighting the defensive strength of both teams. The Steelers have a strong home record (4-2 SU) this season, which could influence betting decisions. The best odds available today for the Steelers are +3.5 at Caesars, while the Bills are favored at -3.5.

These betting trends and game insights suggest a competitive, defensively focused game. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.