Betting Trends Buffalo Bills vs Pittsburgh Steelers

The upcoming NFL Week 13 matchup between the Buffalo Bills and Pittsburgh Steelers is set for November 30, 2025, at Acrisure Stadium in Pittsburgh, PA. This Sunday football game promises an intense clash as both teams look to improve their records and capitalize on home and away advantages. Buffalo, led by starting quarterback Josh Allen, faces a Steelers team starting Aaron Rodgers at QB. Allen’s strong offensive stats, including 234.6 passing yards per game, contrast with Pittsburgh’s robust defense allowing 258.7 passing yards on average, setting the stage for a compelling quarterback duel.

Buffalo’s offense averages 381.8 total yards per game, leveraging a balanced attack with 147.2 rushing yards and strong pass protection. Pittsburgh counters with a solid defense ranked 18th ATS with a 5-6 record, particularly strong at home (4-2 ATS). Buffalo’s away record is 2-3 ATS, indicating some vulnerability on the road. The Bills are favored by 3.5 points with a total points line set at 45.5, reflecting expectations of a moderately high-scoring game.

Injuries could play a role, with Buffalo’s Maxwell Hairston questionable but likely to play after participating fully in practice. Pittsburgh has notable absences like Broderick Jones and Derrick Harmon, which might affect their defensive front. This matchup is broadcast on CBS, making it accessible for fans and bettors alike.

Analyzing betting trends and game insights, Buffalo’s recent performances show a mixed bag with some losses and wins, while Pittsburgh has a solid home record but has also suffered close losses. The Steelers’ pass rush and Buffalo’s pass protection will be crucial factors influencing the spread and total points. Bettors should consider these stats and the 3.5-point spread when making wagers.

For those looking to dive deeper, the last matchup on August 17, 2024, where Buffalo beat Pittsburgh 9-3, offers historical context. The NFL standings page also provides comprehensive ATS records for both teams to inform smarter bets. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.