Buffalo Bills vs Pittsburgh Steelers Betting Trends

The upcoming Sunday football matchup on November 30, 2025, between the Buffalo Bills and Pittsburgh Steelers at Acrisure Stadium in Pittsburgh, PA, is set to be a thrilling NFL regular-season game. Buffalo Bills quarterback Josh Allen leads a potent offensive attack averaging 381.8 total yards per game, bolstered by a strong passing offense that averages 234.6 yards. Meanwhile, the Pittsburgh Steelers, starting with quarterback Mason Rudolph, bring a balanced offense with 292.2 total yards per game and a defense that allows 364.5 yards on average. Both teams have shown strengths in pass protection and pass rush, making this a tactical battle on the line of scrimmage.

Buffalo's defense is stout against the run, allowing just 105.7 rushing yards per game, while Pittsburgh's defense is more vulnerable in this area, conceding 148.9 rushing yards. This could give Buffalo an edge on the ground. The Steelers' pass defense allows 258.7 yards per game, which Buffalo's passing game will look to exploit. The Steelers are favored by 3.5 points with a total points over/under set at 47.5, indicating a moderately high-scoring game. Bettors should consider these betting trends and stats, especially the recent form where Buffalo has a 5-6 ATS record and Pittsburgh holds a 5-6 ATS record, with Pittsburgh performing better at home.

Injuries could play a role, with Buffalo's Michael Hoecht and Landon Jackson on injured reserve, while Pittsburgh's Aaron Rodgers is questionable but expected to play. The game will be broadcast on CBS, providing ample opportunity for fans to catch all the action. For a detailed breakdown and to place a smart wager, check out our OddsTrader Turbo subscription or place your bet with a U.S. regulated sportsbook to capitalize on the edge.

In their last matchup on August 17, 2024, the Bills defeated the Steelers 9-3 at Acrisure Stadium. This historical context adds to the excitement and betting intrigue for this Sunday showdown. The Bills' strong passing offense versus the Steelers' pass defense and the battle of the run games will be key factors to watch.